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Medroxyprogesterone

Steroidal progestin drug

Steroidal progestin drug

Note

a non-clinically used progestin compound

| elimination_half-life =

Medroxyprogesterone (MP), is a progestin which is not used medically. A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison. Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate,

Pharmacology

Pharmacodynamics

Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen. Medroxyprogesterone is also notable in that it is a minor metabolite of MPA. In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor.

CompoundKiaEC50b
Progesterone4.30.925
Medroxyprogesterone2414732
Medroxyprogesterone acetate1.20.60.15
Values are nM. a = Coactivator recruitment. b = Reporter cell line.

Chemistry

Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position. The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related to medrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such as chlormadinone, cyproterone, and megestrol.

Society and culture

Generic names

Medroxyprogesterone is the generic name of the drug and its and .

Brand Name

Meprate 10 Tablets (practo)

References

References

  1. (14 November 2014). "The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies". Springer.
  2. (2000). "Index Nominum 2000: International Drug Directory". Taylor & Francis.
  3. (31 October 1999). "Concise Dictionary of Pharmacological Agents: Properties and Synonyms". Springer Science & Business Media.
  4. "Medroxyprogesterone".
  5. (2009-12-01). "MedroxyPROGESTERone: Drug Information Provided by Lexi-Comp". [[Merck Manual of Diagnosis and Therapy.
  6. (January 1975). "Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits". Annals of Surgery.
  7. (September 2006). "Determination of conformational changes in the progesterone receptor using ELISA-like assays". Steroids.
  8. (January 1976). "The metabolic fate of medroxyprogesterone acetate in the baboon". Journal of Steroid Biochemistry.
  9. (November 2018). "Do progestins contribute to (anti-)androgenic activities in aquatic environments?". Environmental Pollution.
Info: Wikipedia Source

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