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Meclofenoxate

Chemical compound

Summary

Chemical compound

| Drugs.com =

Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests. Meclofenoxate also increases cellular membrane phospholipids. It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.

Side effects

Meclofenoxate is considered to be safe and high in tolerability. However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.

Research

Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 26.5%.

Brand names

In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl. In the US, meclofenoxate is sold as a dietary supplement, although it is an unapproved drug.

References

References

  1. Anvisa. (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (14 November 2014). "The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies". Springer.
  3. (January 2000). "Index Nominum 2000: International Drug Directory". Taylor & Francis.
  4. (October 2022). "The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements". Clinical Toxicology.
  5. (May 1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and Ageing.
  6. (1 January 2003). "The Science of Anti-aging Medicine". American Academy of Anti-Aging Med.
  7. (August 1973). "Effect of dimethylamnioethyl ''p''-chlorophenoxyacetate on the life span of male Swiss Webster Albino mice". Experimental Gerontology.
  8. (22 October 2013). "Drugs in Psychiatric Practice". Elsevier.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

dimethylamino-compounds antidementia-agents carboxylate-esters 4-chlorophenyl-compounds cholinergics nootropics phenol-ethers
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