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McCormack reaction
Chemical reaction
Chemical reaction
The McCormack reaction is a method for the synthesis of organophosphorus compounds. In this reaction, a 1,3-diene and a source of R2P+ are combined to give phospholenium cation. The reaction is named after W. B. McCormack, a research chemist at duPont.
An illustrative reaction involves phenyldichlorophosphine and isoprene: :[[File:McCormackRxn.png|320px]]
The reaction proceeds via a pericyclic [2+4]-process. The resulting derivatives can be hydrolyzed to give the phosphine oxide. Dehydrohalogenation gives the phosphole.
References
References
- W. B. McCormack. (1973). "3-Methyl-1-Phenylphospholene oxide".
- Handbook of organophosphorus chemistry by Robert Engel, CRC Press, 1992. {{ISBN. 0-8247-8733-1.
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