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Manchester score

System of assessing small-cell lung cancer

Manchester score is an indicator of prognosis in small cell lung cancer. It is calculated from a number of physical and biochemical markers.

A patient with small cell lung cancer scores one point for each of the following: -

Serum lactate dehydrogenase exceeds the upper limit of the reference range.
Serum sodium concentration less than 132 mmol/L.
Serum alkaline phosphatase over one-and-a-half times the upper limit of the reference range.
Serum bicarbonate less than 24.
Karnofsky performance status less than 60.
Extensive stage disease.

Prognosis

Manchester score	Prognostic group	Two year survival (%)
0-1	Good	16.2
2-3	Medium	2.5
4 or more	Poor	0

References

Cerny, T. (1987). "Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients". International Journal of Cancer.
Kawahara, Masaaki. (1996). "Prognostic factors and prognostic staging system for small cell lung cancer". Oxford University Press.
Maestu, I. (Jun 1997). "Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients". Annals of Oncology.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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