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Macrophage elastase

Field	Value
Name	Macrophage elastase
EC_number	3.4.24.65
CAS_number	2594837

Macrophage elastase (, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme. This enzyme catalyses the following chemical reaction

: Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-Leu- and -Tyr16-Leu- in the B chain of insulin

This enzyme belongs to the peptidase family M10.

References

(February 1981). "Mouse macrophage elastase. Purification and characterization as a metalloproteinase". The Biochemical Journal.
(May 1981). "The specificity of macrophage elastase on the insulin B-chain". The Biochemical Journal.
(March 1992). "Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase". The Journal of Biological Chemistry.
(November 1993). "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". The Journal of Biological Chemistry.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-3.4.24

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