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List of target antigens in pemphigus

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Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

Pemphigus variant	Antibody isotype	Antigen	Molecular weight (KDa)
Mucosal pemphigus vulgaris	IgG	Desmoglein 3	130
Mucocutaneous pemphigus vulgaris	IgG	Desmoglein 3
Desmoglein 1	130
160
Pemphigus foliaceus	IgG	Desmoglein 1	160
Paraneoplastic pemphigus	IgG	II]] autoantibodies have also been reported in Stevens–Johnson syndrome
Desmoplakin II
Envoplakin
Periplakin
Alpha-2-macroglobulin-like-1	130
160
230
500
250
210
210
190
170
Drug-induced pemphigus	IgG	Desmoglein 3
Desmoglein 1	130
160
Subcorneal pustular dermatosis type of IgA pemphigus	IgA1	Desmocollin 1	110/100
Intraepidermal neutrophilic type of IgA pemphigus	IgA1	Unknown
Parentheticals]] are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.	IgG	Desmoglein 1	160
Fogo selvagem	IgG	Desmoglein 1	160
Pemphigus vegetans	IgG	Desmoglein 3	130
Pemphigus vegetans of HallopeauPemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.	IgG	Desmoglein 3	130
Pemphigus vegetans of Neumann	IgG	Desmoglein 3	130
Pemphigus herpetiformis	IgG	Desmoglein 3
Desmoglein 1	130
160

Footnotes

References

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