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List of target antigens in pemphigoid
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Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.
| Pemphigoid variant | Antibody isotype | Antigen | Molecular weight (KDa) |
|---|---|---|---|
| Bullous pemphigoid | IgG, IgE | NC16A terminal of BPAG2 | |
| BPAG1 | 180 | ||
| 230 | |||
| Gestational pemphigoid | IgG1 | NC16A terminal of BPAG2 | |
| BPAG1 | 180 | ||
| 230 | |||
| Cicatricial pemphigoid | C-terminal of BPAG2 | 180 | |
| Ocular cicatricial pemphigoid | Integrin beta-4 subunit | 200 | |
| Antiepiligrin cicatricial pemphigoidThe antiepiligrin variant of cicatricial pemphigoid is associated with gastric cancer. | Laminin 5 (Epiligrin, Laminin 332) | ||
| Linear IgA bullous dermatosis | LAD1 portion of BPAG2 | ||
| Collagen type VII | |||
| 97 | |||
| 290/145 | |||
| Protein 105 pemphigoid | Protein in lower lamina lucida | 105 |
Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:
| Disease | Antibody isotype | Antigen | Molecular weight (KDa) |
|---|---|---|---|
| Epidermolysis bullosa acquisita | Collagen type VII | 290/145 | |
| Bullous lupus erythematosus | Collagen type VII | 290/145 | |
| bullae]] develop on skin already affected by lesions of lichen planus as well as on areas of skin without lesions of lichen planus. | BPAG2 | 180 |
Footnotes
References
References
- (2012). "Successful Treatment of Bullous Pemphigoid with Omalizumab". Archives of Dermatology.
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