List of San Francisco 49ers first-round draft picks

The San Francisco 49ers (also written as the San Francisco Forty-Niners) are a professional American football team based in the San Francisco Bay Area. The 49ers compete in the National Football League (NFL) as a member of the National Football Conference West Division. The team, founded in 1944 by Tony Morabito, is named after the prospectors who arrived in Northern California in the 1849 Gold Rush. The 49ers joined the NFL prior to the start of the 1950 NFL season. Since 2014 they have played their home games at Levi's Stadium in Santa Clara, California, located southeast of San Francisco.

The NFL draft, officially known as the "NFL Annual Player Selection Meeting", is an annual event which serves as the league's most common source of player recruitment. The draft order is determined based on the previous season's standings; the teams with the worst win–loss records receive the earliest picks. Teams that qualified for the NFL playoffs select after non-qualifiers, and their order depends on how far they advanced, using their regular season record as a tie-breaker. The final two selections in the first round are reserved for the Super Bowl runner-up and champion. Draft picks are tradable and players or other picks can be acquired with them. From through the NFL designated the first overall selection as a "bonus" or "lottery pick". The pick was awarded by a random draw and the winner who received the "bonus pick" forfeited its selection in the final round of the draft and became ineligible for future draws. The system was abolished prior to the 1959 NFL draft, as all twelve teams in the league at the time had received a bonus choice.

Since the team's first NFL draft in 1950, the 49ers have selected 88 players in the first round. The team's first-round pick in their inaugural NFL draft was Leo Nomellini, a defensive tackle from the University of Minnesota; he was the 11th overall selection. The 49ers have drafted first overall three times, selecting Harry Babcock in 1953, Dave Parks in 1964, and Alex Smith in 2005. In the most recent draft, held in 2025, the 49ers chose Georgia defensive end Mykel Williams.

The 49ers did not draft a player in the first round on ten occasions. Nine of the team's first-round picks—Lance Alworth, Jimmy Johnson, Ronnie Lott, Hugh McElhenny, Leo Nomellini, Jerry Rice, Y. A. Tittle, Patrick Willis, and Bryant Young—have been elected to the Pro Football Hall of Fame; one of these, Lance Alworth, chose to sign with the NFL's pre-merger direct competitor, the American Football League (AFL), and never played for the 49ers.

Player selections

Symbol	Meaning	*
Inducted into the Pro Football Hall of Fame
Selected number one overall

Position abbreviations	C	CB	DB	DE	DT	FB	FL	G	HB	LB	QB	RB	S	T	TE	WR
Center
Cornerback
Defensive back
Defensive end
Defensive tackle
Fullback
Flanker
Guard
Halfback
Linebacker
Quarterback
Running back
Safety
Tackle
Tight end
Wide receiver

Season	Pick	Player	Position	College	Notes	1950	1951	1952	1953	1954	1955	1956	1957	1958	1959	1960	1961	1962	1963	1964	1965	1966	1967	1968	1969	1970	1971	1972	1973	1974	1975	1976	1977	1978	1979	1980	1981	1982	1983	1984	1985	1986	1987	1988	1989	1990	1991	1992	1993	1994	1995	1996	1997	1998	1999	2000	2001	2002	2003	2004	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	2019	2020	2021	2022	2023	2024	2025
11		DT	Minnesota
3		QB	LSU
9		HB	Washington
1	*	TE	Georgia	Lottery bonus pick
10		TE	Texas
11		QB	Maryland
10		HB	Rice
2		QB	Michigan State
3		QB	Stanford
8		HB	Michigan	Pick received from Pittsburgh Steelers
9		DT	Texas A&M
5		QB	Oklahoma
8		C	Ohio State	Pick received from Pittsburgh Steelers
11		TE	Notre Dame
6		CB	UCLA	Pick received from Pittsburgh Steelers
9		WR	Bowling Green State
11		QB	UCLA	Pick received from Baltimore Colts
8		FL	Arkansas	Signed for the AFL's San Diego Chargers instead
8		DB	UCLA
1	*	WR	Texas Tech
2		FB	North Carolina
13		DB	Illinois	Pick received from Cleveland Browns
11		T	Ole Miss
3		QB	Florida	Pick received from Atlanta Falcons
11		TE	Northwestern
15		C	Auburn
7		TE	Penn State	Pick received from New Orleans Saints
16		WR	Stanford
9		DE	North Texas
17		DB	Boston	Pick received from Washington Redskins
23		DB	Ohio State
19		WR	Auburn
18		DB	Texas Southern
9		RB	Alabama	Pick received from New England Patriots
10		DT	UCLA
10		DT	Mississippi State
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to New England Patriots
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to New England Patriots
7		TE	Notre Dame
24		LB	Long Beach State	Pick received from Miami Dolphins
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to Buffalo Bills
13		RB	Rice	Moved down draft order in trade with New York Jets
20		DT	Clemson	Pick received from New York Jets
8		DB	USC
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to New England Patriots
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to San Diego Chargers
24		LB	BYU
16		WR	Mississippi Valley State	Moved up draft order in trade with New England Patriots
''{{sortname	No	pick	0	nolink=1}}''	Moved down draft order in trades with Dallas Cowboys and Buffalo Bills
22		T	North Carolina
25		RB	Clemson	Pick received from Washington Redskins
''{{sortname	No	pick	0	nolink=1}}''	Moved down draft order in trade with Los Angeles Raiders
28		LB	Tennessee
25		RB	Florida State
25		DT	Louisville
18		DB	Washington
26		DT	Kansas	Pick received from Kansas City Chiefs and used to move down draft order in trades with Phoenix Cardinals and New Orleans Saints
27		DT	Tennessee
7		DT	Notre Dame	Pick received from San Diego Chargers and used to move up draft order in trade with Los Angeles Rams
28		RB	Florida State	Moved down draft order in trade with Dallas Cowboys
10		WR	UCLA	Moved up draft order in trade with Cleveland Browns
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to Cleveland Browns
26		QB	Virginia Tech
28		CB	Oklahoma State
24		DT	Florida	Moved up draft order in trade with Miami Dolphins
16		LB	Michigan State	Moved down draft order in trade with Washington Redskins and New York Jets
24		CB	Ohio State	Pick received from Washington Redskins
7		DE	California	Moved up draft order in trade with Seattle Seahawks
27		CB	Miami (FL)
26		T	Stanford
31		WR	Oklahoma State	Moved down draft order in trades with Philadelphia Eagles and Carolina Panthers
1	*	QB	Utah
6		TE	Maryland
22		LB	North Carolina State	Moved up draft order in trade with Denver Broncos
11		LB	Ole Miss
28		T	Central Michigan	Pick received from New England Patriots
29		DT	North Carolina	Original pick traded to New England Patriots. Moved up draft order in trade with Indianapolis Colts.
10		WR	Texas Tech
11		T	Rutgers	Moved up draft order in trade with Denver Broncos
17		G	Idaho	Pick received from Carolina Panthers
7		LB	Missouri
30		WR	Illinois
18		S	LSU	Moved up draft order in trade with Dallas Cowboys
30		S	Northern Illinois
17		DE	Oregon	Moved down draft order in trade with San Diego Chargers
7		DE	Oregon
28		G	Stanford	Moved up draft order in trade with Kansas City Chiefs
3		DE	Stanford	Moved down draft order in trade with Chicago Bears
31		LB	Alabama	Moved up draft order in trade with Seattle Seahawks
9		T	Notre Dame
2		DE	Ohio State
14		DT	South Carolina	Pick received from Indianapolis Colts. Moved down draft order in trade with Tampa Bay Buccaneers.
25		WR	Arizona State	Moved up draft order in trade with Minnesota Vikings
3		QB	North Dakota State	Moved up draft order in trade with Miami Dolphins
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to Miami Dolphins
''{{sortname	No	pick	0	nolink=1}}''	Pick traded to Miami Dolphins
31		WR	Florida
11		DE	Georgia