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List of opioids

None


None

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

  • B&O Supprettes
  • Diascordium
  • Dover's powder
  • Kendal Black Drop
  • Laudanum
  • Mithridate
  • Opium
  • Polish heroin (Compote, Kompot)
  • Paregoric
  • Poppy straw concentrate
  • Poppy tea
  • Smoking opium
  • Theriac

Natural opiates

Opium alkaloids

  • Codeine
  • Morphine
  • Oripavine
  • Pseudomorphine
  • Thebaine
Morphides
[[File:Codein - Codeine.svg135 pxChemical structure of codeine.]] Codeine

Alkaloid salts mixtures

  • Pantopon
  • Papaveretum (Omnopon)
  • Tetrapon

Semisynthetics including Bentley compounds

Morphine family

Morphine family
[[File:14-hydroxymorphine.svg135 pxChemical structure of 14-hydroxymorphine.]]14-Hydroxymorphine
[[File:Azidomorphine.png135 pxChemical structure of azidomorphine.]] Azidomorphine
[[File:6-Ethyldihydromorphine.svg135 pxChemical structure of ethyldihydromorphine.]] Ethyldihydromorphine
[[File:RAM-378.svg135 pxChemical structure of RAM-378.]] RAM-378

3,6-diesters of morphine

3,6-diesters of morphine
[[File:Acetylpropionylmorphine.svg135 pxChemical structure of acetylpropionylmorphine.]] Acetylpropionylmorphine
[[File:Dibutyrylmorphine.svg135 pxChemical structure of dibutyrylmorphine.]] Dibutyrylmorphine
[[File:Dipropanoylmorphine.svg135 pxChemical structure of dipropanoylmorphine.]] Dipropanoylmorphine

Codeine-dionine family

Codeine-dionine family
[[File:6-MAC.svg135 pxChemical structure of 6-monoacetylcodeine.]]6-Monoacetylcodeine
[[File:6-Ethyldihydromorphine.svg135 pxChemical structure of ethyldihydromorphine.]] Ethyldihydromorphine
[[File:Pholcodine.svg135 pxChemical structure of pholcodine.]] Pholcodine

Morphinones and morphols

Morphinones and morphols
[[File:14-Cinnamoyloxycodeinone.png135 pxChemical structure of 14-cinnamoyloxycodeinone.]] 14-Cinnamoyloxycodeinone
[[File:8,14-Dihydroxydihydromorphinone.svg135 pxChemical structure of 8,14-dihydroxydihydromorphinone.]] 8,14-Dihydroxydihydromorphinone
[[File:Codeinone.svg135 pxChemical structure of codeinone.]] Codeinone
[[File:Thebacon structure.svg135 pxChemical structure of thebacon.]] Thebacon
[[File:Morphenol.svg135 pxChemical structure of morphenol.]] Morphenol
[[File:Oxymorphol.svg135 pxChemical structure of oxymorphol.]] Oxymorphol

Morphides

Morphides
[[File:Αlpha-chlorocodide.svg135 pxChemical structure of alpha-chlorocodide.]] α-chlorocodide
[[File:Chlorodihydrocodide.svg135 pxChemical structure of chlorodihydrocodide.]] Chlorodihydrocodide.

Dihydrocodeine series

  • 14-Hydroxydihydrocodeine
  • Acetyldihydrocodeine
  • Dihydrocodeine
  • Dihydrodesoxycodeine (desocodeine)
  • Dihydroisocodeine
  • Nicocodeine
  • Nicodicodeine
Morphides
[[File:14-Hydroxydihydrocodeine.svg135 pxChemical structure of 14-hydroxydihydrocodeine.]] 14-Hydroxydihydrocodeine
[[File:Dihydroisocodeine.svg135 pxChemical structure of dihydroisocodeine.]] Dihydroisocodeine

Nitrogen morphine derivatives

Morphides
[[File:1-nitrocodeine.svg135 pxChemical structure of 1-nitrocodeine.]] 1-Nitrocodeine

Hydrazones

  • Acetylmorphazone
  • Hydromorphazone
  • Morphazone--
  • Oxymorphazone
Hydrazones
[[File:Oxymorphazone.png135 pxChemical structure of oxymorphazone.]] Oxymorphazone

Halogenated morphine derivatives

Other open chain opioids
[[File:1-Bromocodeine.svg135 pxChemical structure of 1-bromocodeine.]]

Active opiate metabolites


Active opiate metabolites
[[File:Codeine-N-oxide.svg135 pxChemical structure of codeine-N-oxide.]]Codeine-N-oxide
[[File:Morphine N-oxide.svg135 pxChemical structure of morphine-N-oxide.]]Morphine-N-oxide

Morphinans

[[Levomethorphan

Morphinan series

Other morphinans
[[File:4-chlorophenylpyridomorphinan.svg135 pxChemical structure of 4-chlorophenylpyridomorphinan]] 4-chlorophenylpyridomorphinan
[[File:Levomethorphan.svg135 pxChemical structure of levomethorphan]] Levomethorphan
[[File:Dextromethorphan.svg70 pxChemical structure of dextromethorphan.]] Dextromethorphan [[File:Levomethorphan.svg70 pxChemical structure of Levomethorphan.]] levomethorphan

Others



  • Aknadinine

  • Butorphanol
  • Cephakicine

  • Cephasamine

  • Cyprodime
  • Drotebanol
  • Fenfangjine G
  • Ketorfanol
  • Nalbuphine
  • Nalbuphone
  • Tannagine
Other Morphinans
[[File:1-nitroaknadinine.svg135 pxChemical structure of 1-nitroaknadinine]] 1-Nitroaknadinine
[[File:Butorphanol structure.svg135 pxChemical structure of butorphanol]] Butorphanol
[[File:Fenfangjine G.png135 pxChemical structure of fenfangjine G.]] Fenfangjine G

Benzomorphans

Benzomorphans
[[File:5,9 alpha-diethyl-2-hydroxybenzomorphan.svg135 pxChemical structure of 5,9 alpha-diethyl-2-hydroxybenzomorphan.]][5,9 alpha-diethyl-2-hydroxybenzomorphan
(5,9-DEHB)](5-9-alpha-diethyl-2-hydroxybenzomorphan)
[[File:Butinazocine structure.svg135 pxChemical structure of butinazocine.]] Butinazocine
[[File:Eptazocine.svg135 pxChemical structure of eptazocine.]] Eptazocine
[[File:Gemazocine.svg135 pxChemical structure of gemazocine.]] Gemazocine
[[File:Pentazocine.svg135 pxChemical structure of pentazocine.]] Pentazocine
[[File:Volazocine.svg135 pxChemical structure of volazocine.]] Volazocine

4-Phenylpiperidines

[[Pethidine

Pethidines (meperidines)

  • 4-Fluoropethidine
  • Allylnorpethidine
  • Anileridine
  • Benzethidine
  • Carperidine
  • Difenoxin
  • Diphenoxylate
  • Etoxeridine (carbetidine)
  • Furethidine
  • Hydroxypethidine (bemidone)
  • Morpheridine
  • Meperidine-N-oxide
  • Oxpheneridine (carbamethidine)
  • Pethidine (meperidine)
  • Pethidine intermediate A
  • Pethidine intermediate B (norpethidine)
  • Pethidine intermediate C (pethidinic acid)
  • Pheneridine
  • Phenoperidine
  • Piminodine
  • Properidine (ipropethidine)
  • Sameridine
Pethidines (meperidines)
[[File:4-Fluoropethidine Structure.svg135 pxChemical structure of 4-fluoropethidine.]]4-Fluoropethidine
[[File:Carperidine.svg135 pxChemical structure of carperidine.]] Carperidine
[[File:Hydroxypethidine.svg135 pxChemical structure of hydroxypethidine.]] Hydroxypethidine
[[File:Pethidineintermediate.svg135 pxChemical structure of pethidine intermediate A.]] Pethidine intermediate A
[[File:Piminodine.svg135 pxChemical structure of piminodine.]] Piminodine

Prodines

  • Allylprodine
  • (α/β)-Meprodine
  • Desmethylprodine (MPPP)
  • PEPAP
  • (α/β)-Prodine
  • Prosidol
  • Trimeperidine (promedol)
Prodines
[[File:Allylprodine.svg135 pxChemical structure of allylprodine.]]Allylprodine
[[File:Prosidol.svg135 pxChemical structure of prosidol.]] Prosidol

Ketobemidones

  • Acetoxyketobemidone
  • Droxypropine
  • Ketobemidone
  • Methylketobemidone
  • Propylketobemidone
Ketobemidones
[[File:Acetoxyketobemidone.svg135 pxChemical structure of acetoxyketobemidone.]]Acetoxyketobemidone

Others

  • Alvimopan
  • Loperamide
  • LS-115509
  • Picenadol
Other phenylpiperidines
[[File:Alvimopan.svg135 pxChemical structure of alvimopan.]]Alvimopan

Open chain opioids

[[Methadone

Amidones

Amidones
[[File:Dextromethadone.svg135 pxChemical structure of dextromethadone.]]
[[File:Noracetylmethadol.svg135 pxChemical structure of noracetylmethadol.]] Noracetylmethadol
[[File:Normethadone.svg135 pxChemical structure of normethadone.]] Normethadone

Methadols

  • Acetylmethadol
  • Alphaacetylmethadol
  • Alphamethadol
  • Betacetylmethadol
  • Betamethadol
  • Dimepheptanol (racemethadol)
  • Isomethadol
  • Levacetylmethadol
  • Noracymethadol
Other open chain opioids
[[File:Alphaacetylmethadol.svg135 pxChemical structure of alphaacetylmethadol.]]

Moramides

Other open chain opioids
[[File:Desmethylmoramide.svg135 pxChemical structure of Desmethylmoramide.]]

Thiambutenes

  • cas? --Diethylthiambutene
  • Dimethylthiambutene
  • Ethylmethylthiambutene
  • cas --

  • --Piperidylthiambutene
  • Pyrrolidinylthiambutene
  • Thiambutene
Thiambutenes
[[File:Diethylthiambutene structure.svg135 pxChemical structure of diethylthiambutene.]]
[[File:Piperidylthiambutene Structure.svg135 pxGeneral structure of piperidylthiambutene.]]

Phenalkoxams

  • Dextropropoxyphene (propoxyphene)
  • Dimenoxadol
  • Dioxaphetyl butyrate
  • Levopropoxyphene
  • Norpropoxyphene
  • Pyrroliphene
Phenalkoxams
[[File:Dextropropoxyphene structure.svg135 pxChemical structure of dextropropoxyphene.]]

Ampromides

  • Diampromide
  • Phenampromide
  • Propiram
Ampromides
[[File:Diampromide.svg135 pxChemical structure of diampromide.]]

Others

  • Embutramide
  • IC-26
  • Isoaminile
  • Lefetamine
  • R-4066
Other open chain opioids
[[File:Embutramide2DCSD.svg135 pxChemical structure of embutramide.]]

Anilidopiperidines

[[Fentanyl
Anilidopiperidines
[[File:3-allylfentanyl.svg135 pxChemical structure of 3-allylfentanyl.]]3-Allylfentanyl
[[File:Alphamethylacetylfentanyl.svg135 pxChemical structure of alphamethylacetylfentanyl.]] Alphamethylacetylfentanyl
[[File:Betahydroxythiofentanyl.svg135 pxChemical structure of betahydroxythiofentanyl.]] Betahydroxythiofentanyl
[[File:Lofentanil.svg135 pxChemical structure of lofentanil.]] Lofentanil
[[File:Phenaridine.svg135 pxChemical structure of phenaridine.]] Phenaridine
[[File:Trefentanil Structure.svg135 pxChemical structure of trefentanil.]] Trefentanil

Oripavine derivatives

Thienorphine
Oripavine derivatives
[[File:7-PET.svg135 pxChemical structure of 7-PET.]] 7-PET
[[File:Cyprenorphine Structure.svg135 pxChemical structure of cyprenorphine.]] Cyprenorphine
[[File:N-cyclopropylmethylnoretorphine.svg135 pxChemical structure of N-cyclopropylmethylnoretorphine.]]N-cyclopropylmethylnoretorphine

Phenazepanes

  • Ethoheptazine
  • Meptazinol
  • Metheptazine
  • Metethoheptazine
  • Proheptazine
Phenazepanes
[[File:Ethoheptazine.png135 pxChemical structure of ethoheptazine.]]

Pirinitramides

  • Bezitramide
  • Piritramide
Pirinitramides
[[File:Bezitramide.svg135 pxChemical structure of bezitramide.]]

Benzimidazoles

  • Clonitazene
  • Etonitazene
  • Isotonitazene
  • Metonitazene
Benzimidazoles
[[File:Clonitazene.svg135 pxChemical structure of clonitazene.]]

Indoles

Indoles
[[File:18-Methoxycoronaridine.svg135 pxChemical structure of 18-methoxycoronaridine.]]
[[File:Eseroline_skeletal.svg135 pxGeneral structure of eseroline.]]

Beta-Amino Ketones

Indoles
[[File:3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one.svg200 pxChemical structure of beta-amine ketone 'compound 29']]

Diphenylmethylpiperazines

  • BW373U86
  • DPI-221
  • DPI-287
  • DPI-3290
  • SNC-80
  • AZD-2327
Diphenylmethylpiperazines
[[File:BW373U86.svg135 pxChemical structure of BW373U86.]]

Opioid peptides

[[β-neoendorphin

Dynorphins

  • Big dynorphin
  • Dynorphin A
  • Dynorphin B
  • Leumorphin
Dynorphins
[[File:Noimage.svg135 pxChemical structure of dermenkephalin.]] Big dynorphin

Endomorphins

  • Endomorphin-1
  • Endomorphin-2

Endorphins

  • α-Endorphin
  • β-Endorphin
  • γ-Endorphin
  • α-Neoendorphin
  • β-Neoendorphin
Dynorphins
[[File:Alpha-endorphin.svg135 pxChemical structure of alpha-endorphin.]]
Alpha-endorphin

Enkephalins

  • DADLE
  • DAMGO
  • Deltorphin
  • Met-enkephalin
  • Leu-enkephalin
Enkephalins
[[File:2-D-Alanine-5-D-leucine-enkephalin.png135 pxChemical structure of DADLE.]] DADLE

Propeptides

  • Proenkephalin
  • Proendorphin
  • Proopiomelanocortin

Others / unknown

  • Adrenorphin
  • Amidorphin
  • Biphalin
  • Casokefamide
  • Casomorphins
  • Cytochrophin-4
  • DALDA (Tyr-D-Arg-Phe-Lys-NH2)https://www.ncbi.nlm.nih.gov/pubmed/11860345
  • Deltorphin I
  • Deltorphin II
  • Deprolorphin
  • Dermorphin
  • DPDPE
  • Frakefamide
  • Gliadorphin
  • Gluten exorphins
  • Hemorphin-4
  • Metkefamide
  • Morphiceptin
  • Nociceptin
  • Octreotide
  • Opiorphin
  • Rubiscolin
  • Soymorphins
  • Spinorphin
  • TRIMU 5
  • Tynorphin
  • Valorphin
  • Zyklophin
Other or unknown opioid peptides
[[File:Adrenorphin slim.svg135 pxChemical structure of adrenorphin.]] Adrenorphin
[[File:Dermorphin.svg135 pxChemical structure of dermorphin.]] Dermorphin
[[File:Nociceptin.png135 pxChemical structure of nociceptin.]] Nociceptin

Others

Opioid antagonists and inverse agonists

Biased ligands

Receptor heteromer targeting ligands

  • 6'-GNTI (δ-κ)
  • CYM-51010 (δ-μ)
  • NNTA (κ-μ)
  • IBNtxA (μ1G-NOP)

Uncategorized opioids

  • ADL-5859
  • Alimadol
  • Amentoflavone
  • Anilopam +HCl
  • Asimadoline
  • Cyproterone acetate
  • FE 200665
  • Fedotozine
  • HZ-2
  • Kolokol-1
  • Matrine
  • MCOPPB
  • Menthol
  • MT-7716
  • Nalfurafine
  • Nalorphine
  • Nalorphine dinicotinate
  • PZM21
  • Proglumide
  • Ro65-6570
  • SoRI-9409
  • Spiradoline
  • SR-8993
  • SR-16435
Uncategorized opioids
[[File:Alimadol Structure.svg220 pxChemical structure of alimadol.]]
[[File:FE 200665.svg220 pxChemical structure of FE 200665.]]
[[File:Nalfurafine.svg220 pxChemical structure of nalfurafine.]]
[[File:SoRI-9409 structure.png220 pxChemical structure of SoRI-9409.]]

Combination drug formulations containing opioids

  • Buprenorphine/naloxone
  • Buprenorphine/samidorphan (ALKS-5461)
  • Co-codamol (codeine phosphate/paracetamol)
  • Co-codaprin (codeine phosphate/aspirin)
  • Co-dydramol (dihydrocodeine tartrate/paracetamol)
  • Co-proxamol (dextropropoxyphene/paracetamol)
  • Fentanyl/fluanisone
  • Hydrocodone/ibuprofen
  • Hydrocodone/paracetamol
  • Loperamide/simethicone
  • Morphine/naltrexone
  • Naltrexone/bupropion
  • Oxycodone/aspirin
  • Oxycodone/naloxone
  • Oxycodone/paracetamol

References

References

  1. [http://www.chemindex.com/3371-56-0-cas.html ChemIndex] CAS Registry Number 3371-56-0
  2. [http://www.chemindex.com/509-56-8-cas.html ChemIndex] CAS Registry Number 509-56-8
  3. [http://www.chemindex.com/63715-94-6-cas.html ChemIndex] CAS Registry Number 63715-94-6
  4. [https://pubchem.ncbi.nlm.nih.gov/substance/750205 NCBI PubChem] SID 750205
  5. [http://www.chembase.com/cbid_346222.htm chembase] {{dead link. (January 2018)
  6. (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A..
  7. (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A..
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