List of Major League Baseball single-game home run leaders

In baseball, a home run occurs when the ball is hit in such a way that the batter is able to circle the bases and reach home safely in one play without any errors being committed by the defensive team in the process. In modern baseball the feat is typically achieved by hitting the ball over the outfield fence between the foul poles (or making contact with either foul pole) without first touching the ground, resulting in an automatic home run. There is also the "inside-the-park" home run where the batter reaches home safely while the baseball is in play on the field.

Twenty-one players have hit four home runs in a single Major League Baseball (MLB) game, which writers of Sporting News described as "baseball's greatest single-game accomplishment". The most recent to accomplish the feat to date is Kyle Schwarber with the Philadelphia Phillies against the Atlanta Braves on August 28, 2025. No player has done this more than once in his career. In the pre-professional era, Lipman Pike also hit five home runs in 1866. No player has ever hit four home runs in a postseason game; that record is three, first accomplished by Babe Ruth in Game 4 of the 1926 World Series.

Bobby Lowe was the first to hit four home runs in a single game, doing so on May 30, 1894, for the Boston Beaneaters. Fans were reportedly so excited that they threw $160 in silver coins ($ today) onto the field after his fourth home run. Of all players to achieve the feat, Lowe hit the fewest career home runs, with a total of 71, making his four homers 5.6% of his career total. Two years after Lowe's feat, Ed Delahanty of the Philadelphia Phillies became the second player to hit four home runs in a game. Three other Phillies players have achieved the feat, Chuck Klein in 1936, Mike Schmidt in 1976, and Kyle Schwarber in 2025. Three other current franchises, the Atlanta Braves (with three), the Los Angeles Dodgers (with two), and the Arizona Diamondbacks (with two) have had multiple four-homer games in their history; the former two share the distinction of having one four-homer game in each city they have called home (for the Braves, Boston, Milwaukee, and Atlanta; for the Dodgers, Brooklyn and Los Angeles). The Braves also hold the record for most four-homer games surrendered by a single franchise with four, while the Baltimore Orioles, Chicago Cubs, Cincinnati Reds, and Athletics have each surrendered two such games over their histories. Fourteen of the 30 franchises (as of 2025) have achieved at least one four-homer game, and thirteen franchises have surrendered at least one. Ten have never been involved in a four-homer game at all, although only three of these (Boston Red Sox, Detroit Tigers, Minnesota Twins) date back to before the 1960s expansion era.

Despite Delahanty's achievement on July 13, 1896, the Phillies lost to the Chicago Colts, one of only three occasions when a player hit four home runs but was on the losing team.

These games have resulted in other MLB single-game records due to the extreme offensive performance. Mark Whiten tied Jim Bottomley for the most runs batted in in a single game with 12 in his four-homer game. Shawn Green in 2002 and Nick Kurtz in 2025 each hit a double and a single along with their four home runs for 19 total bases, an MLB record. The previous record was Joe Adcock's mark of 18, which also came from a four-homer game. Carlos Delgado and Eugenio Suárez are the only players to make four plate appearances in a game and hit a home run each time. Warren Spahn pitched the ball which Gil Hodges hit for the first of his four, the only Hall of Fame pitcher faced during a four-home-run game.

As of 2025, of the 21 players who have hit four home runs in a game, 14 players have been eligible for the Hall of Fame, and six have been elected. Players are eligible for the Hall of Fame if they have played in at least 10 major league seasons and have either been retired for five seasons or deceased for at least six months. These requirements exclude three players actively playing for a major league team, one player ineligible who is living and has played in the past five seasons (Martinez), and three (Seerey, Hamilton, and Gennett) who did not play 10 seasons in MLB.