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List of local anesthetics
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This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. Some are primarily of historical interest.
| α-eucaine | β-eucaine | |||
|---|---|---|---|---|
| [[File:Alpha-Eucaine.svg | class=skin-invert-image | frameless | center | upright=0.4]] |
|1900. α β | | | |- |etidocaine |Duranest | |1971 (Takman) |1972 (Lund) | | |- |hexylcaine |Cyclaine, Osmocaine | | | | | |- |fomocaine | |[[File:Fomocaine.png|class=skin-invert-image|frameless|center|upright=0.8]] | | |ester - phenyl | |- |fotocaine | |[[File:Fotocaine.png|frameless|center|upright=0.8]] | | | | |- |hydroxyprocaine | |[[File:Hydroxyprocaine.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | |ester - aminosalicylic | |- |isobucaine | |[[File:Isobucaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]J. R. Reasenberg and S. D. Goldberg, J. Amer. Chem. Soc, 67, 933 (1945). | | |Ester - benzoic | |- |levobupivacaine |Chirocaine | |1990s (Mather and Tucker) |1995 | | |- |lidocaine{{cite web | title = Lignocaine - C14H22N2O | publisher=ChemSpider (lignocaine) |Xylocaine |[[File:Lidocaine.svg|class=skin-invert-image|200px]] |1943 (Nils Löfgren and Bengt Lundqvist) |1947 (Torsten Gordh) | | |- |mepivacaine |Carbocaine, Polocaine | |1956 (Ekenstam and Egner) |1957 (Dhuner) | | |- |meprylcaine |Epirocain | | | | | |- |metabutoxycaine | | | | | | |- |nitracaine | | | | |Ester- Aminobenzoic | |- |orthocaine | | | | | | |- |oxetacaine (oxethazaine) | | | | | | |- |oxybuprocaine |benoxinate, Novesine | | | | | |- |Paraethoxycaine | |[[File:Paraethoxycaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]W. G. Christiansen and S. E. Harris, U. S. Patent 2,404,691 (1946). | | | | |- |phenacaine |Holocaine | | | | | |- |piperocaine |metycaine | | | | | |- |piridocaine | |[[File:Piridocaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]L. A. Walter and R. J. Fosbinder, J. Amer. Chem. Soc, 61, 1713 (1939). | | | | |- |pramocaine |pramoxine | | | | | |- |prilocaine |Citanest | |1959 (Nils Löfgren and Egner) |1960 (Wielding) | | |- |Primacaine | | | | | | |- |procaine |Novocain, borocaine (procaine borate), ethocaine |[[File:Procaine.svg|class=skin-invert-image|200px]] |1904 (Alfred Einhorn) |1905 (Heinrich Braun) | | |- |procainamide | |[[File:Procainamide.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | | | |- |proparacaine |proxymetacaine | | | | | |- |propoxycaine | | | | | | |- |Pyrrocaine | |[[File:Pyrrocaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]N. Lofgren, C. Tegner, and B. Takman, Acta Chem. Scand., 11, 1724 (1957). | | | | |- |quinisocaine (INN) |dimethisoquin (USAN) |[[File:Dimethisoquin.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | | | |- |ropivacaine |Naropin | |1957 (Ekenstam) |1997 | | |- |trimecaine |Mesdicain, Mesocain, Mesokain | | | | | |- |tetracaine |amethocaine, Dicaine, Pontocaine |[[File:2-(dimethylamino)ethyl 4-(butylamino)benzoate 200.svg|class=skin-invert-image|200px]] |1928 (O. Eisleb) |1931 | | |- |Tolycaine | |[[File:Tolycaine.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | | | |- |Tropacocaine | |[[File:Tropacocaine.svg|class=skin-invert-image|200px]] | | | | |- |}
References
References
- (1951). "Über lokalanästhetisch wirksame basische Ester und Amide verschiedener Alkoxy-amino-benzoesäuren". Helvetica Chimica Acta.
- K. Miescher, Helv. Chim. Acta, 15, 163 (1932).
-
- T. H. Rider, J. Amer. Chem. Soc, 52, 2115 (1930).
- M. S. Raasch and W. R. Brode, J. Amer. Chem. Soc, 64, 1112 (1942).
- (1903). "Ueber ein neues p-Menthadiën aus Dihydrocarvylamin". Justus Liebig's Annalen der Chemie.
- G. Meiling, Chem. Ber., 6, 173 (1896).
- H. King, J. Chem. Soc, 125, 41 (1924).
- (2014). "Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine". ACS Chemical Neuroscience.
- W. Grimme and H. Schmitz, Chem. Ber., 84, 734 (1917).
- (February 1952). "Derivatives of 4-Amino-2-hydroxybenzoic Acid. II". Journal of the American Chemical Society.
- T. H. Rider, J. Amer. Chem. Soc, 52, 2115 (1930).
- R. Hiltmann, F. Mietzsch, and W. Wirth, {{US Patent. 2921077 (1960).
- (1909). "CXVI.—Relation between chemical constitution and physiological action in the tropeines. Part II". J. Chem. Soc., Trans..
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