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general/local-anesthetics

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List of local anesthetics

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Summary

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This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. Some are primarily of historical interest.

α-eucaineβ-eucaine
[[File:Alpha-Eucaine.svgclass=skin-invert-imageframelesscenterupright=0.4]]

|1900. α β | | | |- |etidocaine |Duranest | |1971 (Takman) |1972 (Lund) | | |- |hexylcaine |Cyclaine, Osmocaine | | | | | |- |fomocaine | |[[File:Fomocaine.png|class=skin-invert-image|frameless|center|upright=0.8]] | | |ester - phenyl | |- |fotocaine | |[[File:Fotocaine.png|frameless|center|upright=0.8]] | | | | |- |hydroxyprocaine | |[[File:Hydroxyprocaine.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | |ester - aminosalicylic | |- |isobucaine | |[[File:Isobucaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]J. R. Reasenberg and S. D. Goldberg, J. Amer. Chem. Soc, 67, 933 (1945). | | |Ester - benzoic | |- |levobupivacaine |Chirocaine | |1990s (Mather and Tucker) |1995 | | |- |lidocaine{{cite web | title = Lignocaine - C14H22N2O | publisher=ChemSpider (lignocaine) |Xylocaine |[[File:Lidocaine.svg|class=skin-invert-image|200px]] |1943 (Nils Löfgren and Bengt Lundqvist) |1947 (Torsten Gordh) | | |- |mepivacaine |Carbocaine, Polocaine | |1956 (Ekenstam and Egner) |1957 (Dhuner) | | |- |meprylcaine |Epirocain | | | | | |- |metabutoxycaine | | | | | | |- |nitracaine | | | | |Ester- Aminobenzoic | |- |orthocaine | | | | | | |- |oxetacaine (oxethazaine) | | | | | | |- |oxybuprocaine |benoxinate, Novesine | | | | | |- |Paraethoxycaine | |[[File:Paraethoxycaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]W. G. Christiansen and S. E. Harris, U. S. Patent 2,404,691 (1946). | | | | |- |phenacaine |Holocaine | | | | | |- |piperocaine |metycaine | | | | | |- |piridocaine | |[[File:Piridocaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]L. A. Walter and R. J. Fosbinder, J. Amer. Chem. Soc, 61, 1713 (1939). | | | | |- |pramocaine |pramoxine | | | | | |- |prilocaine |Citanest | |1959 (Nils Löfgren and Egner) |1960 (Wielding) | | |- |Primacaine | | | | | | |- |procaine |Novocain, borocaine (procaine borate), ethocaine |[[File:Procaine.svg|class=skin-invert-image|200px]] |1904 (Alfred Einhorn) |1905 (Heinrich Braun) | | |- |procainamide | |[[File:Procainamide.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | | | |- |proparacaine |proxymetacaine | | | | | |- |propoxycaine | | | | | | |- |Pyrrocaine | |[[File:Pyrrocaine.svg|class=skin-invert-image|frameless|center|upright=0.8]]N. Lofgren, C. Tegner, and B. Takman, Acta Chem. Scand., 11, 1724 (1957). | | | | |- |quinisocaine (INN) |dimethisoquin (USAN) |[[File:Dimethisoquin.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | | | |- |ropivacaine |Naropin | |1957 (Ekenstam) |1997 | | |- |trimecaine |Mesdicain, Mesocain, Mesokain | | | | | |- |tetracaine |amethocaine, Dicaine, Pontocaine |[[File:2-(dimethylamino)ethyl 4-(butylamino)benzoate 200.svg|class=skin-invert-image|200px]] |1928 (O. Eisleb) |1931 | | |- |Tolycaine | |[[File:Tolycaine.svg|class=skin-invert-image|frameless|center|upright=0.8]] | | | | |- |Tropacocaine | |[[File:Tropacocaine.svg|class=skin-invert-image|200px]] | | | | |- |}

References

References

  1. (1951). "Über lokalanästhetisch wirksame basische Ester und Amide verschiedener Alkoxy-amino-benzoesäuren". Helvetica Chimica Acta.
  2. K. Miescher, Helv. Chim. Acta, 15, 163 (1932).
    1. T. H. Rider, J. Amer. Chem. Soc, 52, 2115 (1930).
  3. M. S. Raasch and W. R. Brode, J. Amer. Chem. Soc, 64, 1112 (1942).
  4. (1903). "Ueber ein neues p-Menthadiën aus Dihydrocarvylamin". Justus Liebig's Annalen der Chemie.
  5. G. Meiling, Chem. Ber., 6, 173 (1896).
  6. H. King, J. Chem. Soc, 125, 41 (1924).
  7. (2014). "Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine". ACS Chemical Neuroscience.
  8. W. Grimme and H. Schmitz, Chem. Ber., 84, 734 (1917).
  9. (February 1952). "Derivatives of 4-Amino-2-hydroxybenzoic Acid. II". Journal of the American Chemical Society.
  10. T. H. Rider, J. Amer. Chem. Soc, 52, 2115 (1930).
  11. R. Hiltmann, F. Mietzsch, and W. Wirth, {{US Patent. 2921077 (1960).
  12. (1909). "CXVI.—Relation between chemical constitution and physiological action in the tropeines. Part II". J. Chem. Soc., Trans..
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