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Lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase

Class of enzymes

Field	Value
Name	Lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
EC_number	2.4.2.43

Lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase (, undecaprenyl phosphate-alpha-L-Ara4N transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, polymyxin resistance protein PmrK, arnT (gene)) is an enzyme with systematic name 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate:lipid IVA 4-amino-4-deoxy-L-arabinopyranosyltransferase. This enzyme catalyses the following chemical reaction

: (1) 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate + alpha-Kdo-(2-4)-alpha-Kdo-(2-6)-lipid A \rightleftharpoons alpha-Kdo-(2-4)-alpha-Kdo-(2-6)-[4-P-L-Ara4N]-lipid A + ditrans, octacis-undecaprenyl phosphate : (2) 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate + lipid IVA \rightleftharpoons lipid IIA + ditrans, octacis-undecaprenyl phosphate : (3) 4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate + alpha-Kdo-(2-4)-alpha-Kdo-(2-6)-lipid IVA \rightleftharpoons 4'-alpha-L-Ara4N-alpha-Kdo-(2-4)-alpha-Kdo-(2-6)-lipid IVA + ditrans, octacis-undecaprenyl phosphate

This integral membrane protein is present in the inner membrane of certain Gram negative endobacteria.

References

(November 2001). "An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor". The Journal of Biological Chemistry.
(November 2001). "Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm". The Journal of Biological Chemistry.
(November 2001). "Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation". The Journal of Biological Chemistry.
(March 2006). "Purification and characterization of the L-Ara4N transferase protein ArnT from Salmonella typhimurium". Protein Expression and Purification.
(January 2010). "Identification of a functionally important loop in Salmonella typhimurium ArnT". Biochemistry.

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ec-2.4.2

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