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Leiner's disease

Field	Value
name	Leiner's disease
field	Dermatology

Leiner's disease is a systemic disease, a skin disorder and extends to erythroderma, typically diagnosed in early infancy. Leiner's disease is characterized by a long-lasting seborrhea dermatitis associated with increased likelihood to infection. Other characterizations found on newborns with Leiner's disease are a patch or a large patch of red skin normally on the bottom and spreads to the rest of the body. This disease is also listed as a "rare disease", meaning that a small percent of the population, fewer than 200,000 people in the United States, will have this disorder.

Symptoms

Symptoms include severe seborrheic dermatitis of the scalp, severe diarrhea, recurrent local and systemic infection, central nervous system problems, and failure to thrive. Other symptoms also include scaling on the trunk and limbs, red patches of skin on parts of the body that bend, fevers, reduced blood protein levels, thick red skin patches, peeling of the skin, itching, corneal ulcers. wasting of the lymph nodes, underdeveloped lymphatics, anemia, wasting, and nervous system deficiency.

It is caused by a deficit of the complement protein, C5; however, case reports have described it in relation to deficits in either C3 or C4.

Cause

The exact cause of Leiner disease remains unknown but biotin deficiency linked to Complement component 5 (a protein ) coded by the C5 gene plays a role.

Diagnosis

This disease is often found during the first two months of an infant's life, breast-fed infants with a higher chance. Male and female infants are affected equally.

Treatment

Hospitalization for the diseased person is suggested because of the controlled environment because it may prevent nutritional deficiencies and skin infections. A decrease in severity of symptoms usually happens after a few weeks when treated redness and scaliness usually do not recur. In 10 percent of cases, the result of uncontrolled infections or severe electrolyte loss may be fatal.

Epidemiology

The cause of this disease is unknown; some infants may have a severe case, others may have immunodeficiency.

References

(July 2015). "Physicians' guide to rare diseases". Dowden.
"Healthgrades Health Library".
"Leiner's disease".
(July 2015). "Manual of Skin Diseases".
{{EMedicine. article. 135478. Complement Deficiencies

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

seborrheic-dermatitis syndromes

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