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Large cell neuroendocrine carcinoma of the lung

Human disease

Human disease

Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. It is currently considered to be a subtype of large-cell lung carcinoma.

LCNEC is often generically grouped among the non-small-cell lung carcinomas.

LCNECs often have inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%).

Variants

The World Health Organization classification of lung tumors recognizes a variant of LCNEC, namely "combined large-cell neuroendocrine carcinoma" (c-LCNEC).

References

References

  1. (2004). "Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart". IARC Press.
  2. (2018). "Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors". Nature Communications.
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