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Large-cell lymphoma

Field	Value
name	Large-cell lymphoma
image	Primary mediastinal large B-cell lymphoma - high mag.jpg
caption	Micrograph of a primary mediastinal large B-cell lymphoma, a type of large-cell lymphoma. H&E stain.
field	Oncology

The large-cell lymphomas have large cells. One classification system for lymphomas divides the diseases according to the size of the white blood cells that have turned cancerous. A large cell, in this context, has a diameter of 17 to 20 μm. Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas.

Types

B cell

Diffuse large B-cell lymphoma is the most common of the large-cell lymphomas. MeSH now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".

Many other B-cell lymphomas feature large cells:

Angiocentric lymphoma
Burkitt's lymphoma
Follicular large-cell lymphoma
Immunoblastic lymphoma
Intravascular large-cell lymphoma
Primary mediastinal B-cell lymphoma
T-cell–rich B-cell lymphoma
Primary splenic lymphoma (rare)
Primary central nervous system lymphomas, which are often diffuse large-B-cell lymphomas
Richter's transformation: Diffuse Large B-cell Variant
1. ABC subtype (common)
1. GCB subtype (rare)

Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway. This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously. The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.

T cell

Less commonly, a large-cell lymphoma may feature T cells. Anaplastic large-cell lymphoma is an example of a large-cell lymphoma that involves T cells. Of the large-cell T-cell lymphomas, it has the best prognosis.

References

Turgeon, Mary Louise. (2005). "Clinical hematology: theory and procedures". Lippincott Williams & Wilkins.
{{MeshName. Large+cell+lymphoma

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

non-hodgkin-lymphoma

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