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Laboratory animal allergy

Occupational disease

Occupational disease

Laboratory animal allergy (LAA) is an occupational disease of laboratory animal technicians and scientists. It manifests as an allergic response to animal urine, specifically the major urinary proteins (Mups) of rodents, and can lead to the development of asthma. A study of 5641 workers in Japan who were exposed to laboratory animals found 23.1% had one or more allergic symptoms; globally the prevalence among at risk workers is estimated between 11 and 30% According to the National Institutes of Health, prevention of animal allergy depends on the control of allergens in the work environment. This involves a combination of measures to eliminate or control allergen exposure, including engineering controls, administrative controls, and personal protective equipment.

The protein product of the mouse Mup17 gene, known as Mus m 1, Ag1 or MA1, accounts for much of the allergenic properties of mouse urine. Similarly, the product of the rat Mup13 gene, Rat n 1, is also a potent human allergen.

Notes

References

  1. (September 2003). "Prevention of laboratory animal allergy". Occupational Medicine.
  2. Wood RA. (2001). "Laboratory animal allergens". ILAR Journal.
  3. (2008). "Allergens and Allergen Immunotherapy". Informa Health Care.
  4. (January 1992). "Allergy to laboratory animals: an epidemiological study". British Journal of Industrial Medicine.
  5. ''The National Institutes of Health Laboratory Animal Allergy Prevention Program'' [https://web.archive.org/web/20060929084532/http://dohs.ors.od.nih.gov/pdf/LAAPP.pdf]
  6. (1989). "Suppression of ouabain-insensitive K-ATPase activity in rabbit nephron segments during chronic hyperkalemia". Renal Physiology and Biochemistry.
  7. (November 1986). "Immunologic and biochemical properties of the major mouse urinary allergen (Mus m 1)". The Journal of Allergy and Clinical Immunology.
  8. (March 1987). "Occupational asthma and rhinitis related to laboratory rats: serum IgG and IgE antibodies to the rat urinary allergen". The Journal of Allergy and Clinical Immunology.
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