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L-Glucose

L-isomer of glucose

Summary

L-isomer of glucose

-Glucose is an organic compound with formula C6H12O6 or O=CH[CH(OH)]5H, specifically one of the aldohexose monosaccharides. As the -isomer of glucose, it is the enantiomer of the more common -glucose.

-Glucose does not occur naturally in living organisms, but can be synthesized in the laboratory. -Glucose is indistinguishable in taste from -glucose,

Like the -isomer, -glucose usually occurs as one of four cyclic structural isomers—α- and β--glucopyranose (the most common, with a six-atom ring), and α- and β--glucofuranose (with a five-atom ring). In water solution, these isomers interconvert in matters of hours, with the open-chain form as an intermediate stage.

Uses

-Glucose was once proposed as a low-calorie sweetener and it is suitable for patients with diabetes mellitus, but it was never marketed due to excessive manufacturing costs.

The acetate derivative of -glucose, -glucose pentaacetate, was found to stimulate insulin release, and might therefore be of therapeutic value for type 2 diabetes.

-Glucose was also found to be a laxative, and has been proposed as a colon-cleansing agent which would not produce the disruption of fluid and electrolyte levels associated with the significant liquid quantities of bad-tasting osmotic laxatives conventionally used in preparation for colonoscopy.

References

References

  1. (1979). "Oxidation of l-glucose by a Pseudomonad". Biochimica et Biophysica Acta (BBA) - Enzymology.
  2. "A Natural Way to Stay Sweet". NASA.
  3. Malaisse, W. J.. (1998). "The riddle of L-glucose pentaacetate insulinotropic action". Int. J. Mol. Med..
  4. (2003). "An open-label trial of L-glucose as a colon-cleansing agent before colonoscopy". Gastrointest. Endosc..
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

aldohexoses sugar-substitutes laxatives pyranoses furanoses
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