Surf Wiki
Save to docs
general/dipeptides

From Surf Wiki (app.surf) — the open knowledge base

Kyotorphin

L-Tyrosyl-L-arginine

Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain, by Japanese scientists in 1979. Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that its concentration is lower in patients with persistent pain.

References

References

  1. (November 1979). "A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser". Nature.
  2. (2017). "Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives". Frontiers in Pharmacology.
  3. (2021). "Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics". Frontiers in Medical Technology.
  4. (November 1991). "[Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain]". Masui.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

dipeptides
Want to explore this topic further?

Ask Mako anything about Kyotorphin — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report