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Kv channel interacting protein

Kv channel interacting proteins are members of a family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.

Members of this family include:

  • KCNIP1, a protein that in humans is encoded by the KCNIP1 gene.
  • KCNIP2, a protein that in humans is encoded by the KCNIP2 gene.
  • KCNIP3, more commonly known as Calsenilin, a protein that in humans is encoded by the KCNIP3 gene.
  • KCNIP4, a protein that in humans is encoded by the KCNIP4 gene.

References

References

  1. Burgoyne RD. (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci..
  2. "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
  3. (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature.
  4. (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med.
  5. (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature.
  6. (Jan 2002). "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain". Proc Natl Acad Sci U S A.
  7. (Apr 2002). "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem.
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