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Kofler bench
Molecular temperature measurement tool
Molecular temperature measurement tool

A Kofler bench, or Kofler heating bar; Kofler hot bar; Kofler hot bench, in German, Kofler-Heizbank, is a metal strip with a temperature gradient (range room temperature to 300°C). Any substance can be placed on a section of the strip revealing its thermal behaviour at the temperature at that point. The gradient is engineered to be approximately linear.
This melting-point apparatus for use with a microscope was developed by the Austrian pharmacognosist Ludwig Kofler (30 November 1891 Dornbirn - 23 August 1951 Innsbruck) and his wife mineralogist Adelheid Kofler. In 1936, the Koflers and Mayrhofer published their "Mikroskopische Methoden in der Mikrochemie" [Kofler, L., A. Kofler and Mayrhofer, A. (1936)], Kofler and Kofler published their "Thermomikromethoden" [Kofler L., and A. Kofler (1954)] in 1954. The integration of microscope and Kofler bench is known as the Kofler hot stage microscope.
Kofler, his wife Adelheid, and their colleague, Maria Kuhnert-Brandstätter, investigated numerous organic molecules, and published some 250 papers describing their work.
Thermomicroscopy, incepted by Ludwig and Adelheid Kofler and developed further by Maria Kuhnert-Brandstätter (1919–2011) and Walter C. McCrone used the technique for studying the phases of solid drug substances.
References
References
- Neuberg, Bill. (24 April 2018). "Kofler hot bench: repair of a class melting point determination apparatus".
- "Archived copy".
- (24 April 2018). "The Kofler Hot Bench: Repair of a Classic Melting Point Determination Apparatus".
- (2006-02-26). "The Literature of Classical Microchemistry, Spot Tests, and Chemical Microscopy".
- [https://books.google.com/books?id=r__FmMNS7qIC&dq=Ludwig+Kofler+%281891-1951%29&pg=PA360 History of Pharmacy]
- (2020). "Hot stage microscopy and its applications in pharmaceutical characterization". Applied Microscopy.
- "In Journal: Crystal Growth & Design : Search".
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