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Kinesin 8

The Kinesin 8 Family are a subfamily of the molecular motor proteins known as kinesins. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP-hydrolysis-created energy. The Kinesin 8 family has been shown to play an important role in chromosome alignment during mitosis. Kinesin 8 family members KIF18A in humans and Kip3 in yeast have been shown to be in vivo plus-end directed microtubule depolymerizers. During prometaphase of mitosis, the microtubules attach to the kinetochores of sister chromatids. Kinesin 8 is thought to play some role in this process, as knockdown of this protein via siRNA produces a phenotype of sister chromatids that are unable to align properly.

References

(Mar 2007). "The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression". Curr. Biol..
(Sep 2006). "Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle". Nat. Cell Biol..
(Feb 2008). "The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment". Dev Cell.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

motor-proteins

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