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Khat

Psychoactive species of plant

Khat

Summary

Psychoactive species of plant

Khat (Catha edulis), also known as Bushman's tea, especially in South Africa, is a flowering plant native to eastern and southeastern Africa. It has a history of cultivation originating in the Harar area (present day eastern Ethiopia) and subsequently introduced at different times to countries nearby in East Africa and Southern Arabia, most notably Yemen. Cultivated by farmers, its leaves are sold on the market to be chewed as a recreational stimulant. The world's largest consumers are Eastern Africans, particularly Somalis, and nearby Yemen, with the largest producers/exporters being Ethiopia and Kenya.

Khat contains the alkaloid cathinone, a stimulant which causes greater sociability, excitement, mild loss of appetite and mild euphoria. Among communities from the areas where the plant is native, khat-chewing has historical relevance (as a social custom, especially among men) dating back thousands of years, analogous—but slightly different—to the use of coca leaves in South America's Andes Mountains or the betel nut preparations in South Asia.

Since 1980, the World Health Organization (WHO) classifies khat as a "drug of abuse" that can produce psychological dependence, although the WHO does not consider khat addiction to be a serious global problem.

The legality of khat varies by region and country; in many territories, khat might pass "under-the-radar" as a botanical species (thus not be a specifically controlled substance), but its recreational use may, nevertheless, be illegal under more general laws.

It is strictly a controlled substance in many regions, often at the highest degree, including in Australia, Canada, the European Union, India, Jordan, New Zealand, Saudi Arabia, the United Arab Emirates (UAE) and the United Kingdom (UK). In the United States (US) and Turkey, the botanical specimen (plant) Catha edulis is not prohibited, but the consumption and distribution of harvested leaves or possession for recreational use is illegal. In the UAE, the punishment for possession, use, or distribution of khat can include life imprisonment.

By contrast, its production, sale, and consumption are all fully legal—or not mentioned in a legal context at all—in the nations where its use is culturally significant, including Djibouti, Ethiopia, Kenya, Somalia, Sudan, Uganda and Yemen. In Israel, which hosts a population of Yemenite Jews, only the consumption of the plant's leaves in its natural state is permitted; "khat extracts" are illegal, after they became a street drug and were popularly abused in the 2000s.

Nomenclature

The genus name Catha is a Latinization of the Arabic name قات, which is regularly romanized as qāt. Other romanizations include kat, quatt, qaad, qhat, ghat, and chat.

The khat plant is known by a variety of names, such as qat and gat in Yemeni Arabic, qaat and jaad in Somali, and chat in Harari and Amharic. It is also known as jimaa in the Oromo language, mayirungi in Luganda, and as miraa and muguka in Swahili. In the African Great Lakes region, where Catha edulis is (in some areas) cultivated, it is known as miraa, muhulo, muguka and muirungi.

It also goes by various descriptive names, such as Abyssinian tea, Arabian tea, kafta, jimaa, and Somalian tea in its endemic regions of the Horn of Africa and the Arabian peninsula. In South Africa, the plant is known as Bushman's tea. The plant is also known as chat tree and flower of paradise.

Vernacular names

In the Indian subcontinent, Catha edulis is sometimes referred to by its Unani name Kat or Qaat in traditional texts.

Description

Khat leaves of [[Harar

Khat is a slow-growing shrub or tree that typically attains a height of 1-5 m. However, it can reach heights of up to 10 m in equatorial areas. The plant usually grows in arid environments, at a temperature range of 5 -. It has evergreen leaves, which are 5–10 cm long and 1-4 cm broad.

Qat tree, Yemen

It takes seven to eight years for the khat plant to reach its full height. Other than access to sun and water, khat requires little maintenance. Ground water is often pumped from deep wells by diesel engines to irrigate the crops, or brought in by water trucks. The plants are watered heavily starting around a month before they are harvested to make the leaves and stems soft and moist. A good khat plant can be harvested four times a year, providing a year-long source of income for the farmer.

The shrub's flowers are produced on short axillary cymes that are 4-8 cm in length. Each flower is small, with five white petals.

The samara fruit is an oblong, three-valved capsule, which contains one to three seeds.

Society and culture

Cultivation

Khat cultivation in western Yemen near [[At Tawilah

Khat has been grown for use as a stimulant for centuries in the Horn of Africa and the Arabian peninsula. There, chewing khat predates the use of coffee and is used in a similar social context. Its fresh leaves and tops are chewed or, less frequently, dried and consumed as tea, to achieve a state of euphoria and stimulation. The leaves or the soft part of the stem can be chewed with either chewing gum or fried peanuts to make it easier to chew.

In Uganda, it is grown in the central region, especially in Kasenge (Wakiso), Butambala District, Mabira Forest, and in some parts of the western region of the country. In Kenya, it is grown in Meru County and Embu County.

One reason for the widespread cultivation of khat in Yemen is the high income that it provides for farmers. Some studies done in 2001 estimated that the income from cultivating khat was about 2.5 million Yemeni rials per hectare, while fruits brought only 0.57 million rials per hectare. Between 1970 and 2000, the area on which khat was cultivated was estimated to have grown from 8,000 to 103,000 hectares. In 2000, according to a World Bank estimate, khat accounted for 30% of Yemen's economy.

Uses

A khat picnic in Yemen

Although the practice of khat-chewing is still primarily restricted to its original area of cultivation in the Red Sea area, the khat plant is native to the whole of the eastern side of Africa from Kenya southwards to Tanzania, Malawi, Zambia, Zimbabwe, where it grows on rocky outcrops and around the fringes of woodlands. In southern Africa the shrub's range is scattered but still grows in the KwaZulu-Natal, Eastern Cape, Western Cape and Mpumalanga provinces of South Africa, in addition to Eswatini and Mozambique.

Traditionally, khat is used as a socialising drug as in Yemen, where khat-chewing is predominantly a male habit combined with conversation, hookah smoking, and tea drinking. Khat is so popular in Yemen that its cultivation consumes much of the country's agricultural resources. An estimated 40% of Yemen's water supply goes towards irrigating it, with production increasing by about 10% to 15% every year. One "daily bag" of khat requires an estimated 500 L of water to produce. Water consumption is high and groundwater levels in the Sanaa basin are diminishing, so government officials have proposed relocating large portions of the population of the city to the Red Sea coastal areas.

In countries outside the core area of growth and consumption, khat is sometimes chewed at parties or social functions. It may also be used by farmers and labourers for reducing physical fatigue or hunger, and by drivers and students for improving attention.

More recently, in 2019, reports indicate that child soldiers in Yemen have been chewing khat in order to remain alert on the battlefield.

Distribution

Qat dealers

In recent years, improved roads, off-road motor vehicles, and air transportation have increased the global distribution of this perishable commodity and, as a result, the plant has been found in places such as Australia, Netherlands, Canada, the United Kingdom, the Levant, Rome (Italy), New Zealand and the United States. In the US, freshly-packed khat leaves are sold in the African and Middle Eastern markets of Boston, Dallas, Los Angeles, and New York City, where the demand is highest.

Effects

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Medieval Mamluk historian al-Maqrizi describing Khat's effects states:

Khat consumption induces mild euphoria and excitement, similar to that conferred by strong coffee. Individuals become very talkative under the influence of the plant. Animal testing has shown that khat causes an increase in motoric activity. The effects of oral administration of cathinone occur more rapidly than the effects of amphetamine pills; roughly 15 minutes as compared to 30 minutes in amphetamine. Khat can induce manic behaviours and hyperactivity, similar in effects to those produced by amphetamine.

The use of khat results in constipation. Dilated pupils (mydriasis) are prominent during khat consumption, reflecting the sympathomimetic effects of the drug, which are also reflected in increased heart rate and blood pressure. Long-term use can precipitate permanent tooth darkening (of a greenish tinge), susceptibility to ulcers, and diminished sex drive. Khat is an effective anorectic, causing loss of appetite.

It is unclear if the consumption of khat directly affects the mental health of the user or not. Occasionally, a psychotic episode can result, resembling a hypomanic state in presentation. In humans, its prolonged consumption creates an uplifted mood and a sense of release from time and space.

Khat is mainly chewed by men, but there are cases of its use by women, and in particular it has been associated with increased likelihood of adverse outcomes during pregnancy.

Effects by timeframe

Immediate

  • alertness
  • arousal
  • concentration
  • confidence
  • constipation
  • dilated pupils
  • euphoria
  • friendliness
  • increased blood pressure
  • increased heart rate
  • insomnia
  • mania
  • psychosis
  • suppressed appetite
  • talkativeness
  • thought disorder
  • verbosity

Long-term

  • depression
  • infrequent hallucinations
  • impaired inhibition (similar to alcohol)
  • increased risk of myocardial infarction (heart attack)
  • oral cancer
  • psychosis in extreme cases in the genetically predisposed
  • weight loss

Indeterminate

  • death
  • stroke following acute coronary syndrome (clogging of the artery)either from impaired insight into symptoms by the khat chewer, delay to care, or poorly understood pathophysiological mechanisms

Chemistry and pharmacology

Cathinone structure

The stimulant effect of the plant was originally attributed to "katin", cathine, a phenethylamine-type substance isolated from the plant. However, the attribution was disputed by reports showing the plant extracts from fresh leaves contained another substance more behaviourally active than cathine. In 1975, the related alkaloid cathinone was isolated, and its absolute configuration, (S)-2-Amino-1-phenylpropan-1-one, was established in 1978. Cathinone is not very stable and breaks down to produce cathine and norephedrine. These chemicals belong to the PPA (phenylpropanolamine) family, a subset of the phenethylamines related to amphetamines and the catecholamines epinephrine and norepinephrine. In fact, cathinone and cathine have a very similar molecular structure to amphetamine. Khat is sometimes confused with methcathinone (also known as cat), a Schedule I substance that possesses a similar chemical structure to the khat plant's cathinone active component. However, both the side effects and the addictive properties of methcathinone are much stronger than those associated with khat use.

When khat leaves dry, the more potent chemical, cathinone, decomposes within 48 hours, leaving behind the milder chemical, cathine. Thus, harvesters transport khat by packaging the fresh leaves and stems in plastic bags or wrapping them in banana leaves to preserve their moisture and keep the cathinone potent. It is also common for them to sprinkle the plant with water frequently or use refrigeration during transportation.

When the khat leaves are chewed, cathine and cathinone are released and absorbed through the mucous membranes of the mouth as well as the lining of the stomach. The action of cathine and cathinone on the reuptake of epinephrine and norepinephrine has been demonstrated in lab animals, showing that one or both of these chemicals cause(s) the body to recycle these neurotransmitters more slowly, resulting in the wakefulness and insomnia associated with khat use.

Receptors for serotonin show a high affinity for cathinone, suggesting this chemical is responsible for feelings of euphoria associated with chewing khat. In mice, cathinone produces the same types of nervous pacing or repetitive scratching behaviours associated with amphetamines. The effects of cathinone peak after 15 to 30 minutes, with nearly 98% of the substance metabolised into norephedrine by the liver.

Cathine is somewhat less understood, being believed to act upon the adrenergic receptors causing the release of epinephrine and norepinephrine. It has a half-life of about three hours in humans. The medication bromocriptine can reduce cravings and withdrawal symptoms within 24 hours.

Demographics

Man in [[Mogadishu]] dividing khat into bunches for guests in preparation for a long evening of tea, conversation and chewing

An estimated 5 to 10 million people globally use khat on a daily basis. It is grown principally by communities in the Horn of Africa and the Arabian peninsula, where khat-chewing has a long history as a social custom dating back thousands of years.

The traditional form of khat chewing in Yemen involves only male users; khat chewing by females is less formal and less frequent. Researchers estimate about 70–80% of Yemenis between 16 and 50 years old chew khat, at least on occasion. Approximately 60–90% of male and 35% of female Yemenis chew khat daily. Before Yemeni unification in 1990, khat chewing was largely confined to the north-west mountains of the country, where khat grows. Yemenis spend an estimated 14.6 million man-hours per day chewing khat. Researchers have also estimated that families spend about 17% of their income on khat.

In Ethiopia, khat is chewed by 19.5% of the population and is more commonly chewed by men than women.

History

Man chewing khat in [[Sanaa]], Yemen (January 2009)

The inhabitants of Ifat Sultanate were the first to be recorded using khat in the 14th century by Arab historian Ibn Fadlallah al-Umari. The khat plant likely originated in the Horn of Africa specifically Ethiopia-Somali area, from there it spread to Kenya and the Arabian Peninsula. According to nineteenth century British explorer Richard Burton, khat originated in the Emirate of Harar.

Muslim Sufis in the surrounding areas also used it to intensify their mystical experience and to facilitate a sense of union with God.

The earliest known documented description of khat is found in the Kitab al-Saidala fi al-Tibb كتاب الصيدلة في الطب, an 11th-century work on pharmacy and materia medica written by Abū Rayhān al-Bīrūnī, a Persian scientist and biologist. Unaware of its origins, al-Bīrūnī wrote that khat is:

It is mentioned again in a 13th-century publication by the physician Naguib Ad-Din.

In 1854, Malay author Abdullah bin Abdul Kadir noted that the custom of chewing khat was prevalent in Al Hudaydah in Yemen:

In 1856, English writer Charles Dickens also described the custom of khat chewing in the Horn region and the adjacent Gulf territories, likening it to drinking strong green tea:

Harari]] men consuming khat in the street of [[Harar]], Ethiopia

Nowadays khat consumption is limited to East Africa and South Western Arabia. These countries include Djibouti, Ethiopia, Kenya, Somalia (includes Somaliland), Uganda, and Yemen. The author Yousif Al Zarouni writes in his book:

The plant is mostly used by East Africans and South West Arabians, rarely by people from other places.}}

Following a ban on khat in the British-governed Aden Protectorate, the Qāt Commission of Inquiry in Aden concluded: "Qāt does not create an addiction, like opium or hashish, in that those who are suddenly deprived of it, do not suffer physical consequences."

Biofuel

The possibility of Khat waste has been explored as a biofuel. It may be a possible future fuel, especially in developing countries. Some chemical groups that are essential for biofuel properties, such as alkene groups and O-H bonds have been found in Khat waste.

Research programs

In 2009, the University of Minnesota launched the Khat Research Program (KRP), a multidisciplinary research and training program focusing on the neurobehavioral and health effects of khat, led by Mustafa al'Absi. The program was funded by the National Institutes of Health and the National Institute for Drug Abuse of the United States. The inaugural event for the KRP was held in Sharm El-Sheik, Egypt, in December, 2009 in collaboration with the International Brain Research Organization (IBRO) and its local affiliates.

Notes

References

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