Kendomycin

Total synthesis

Because of its potent biological activities, kendomycin has attracted interest as a target of total synthesis. The first total synthesis of kendomycin was accomplished by Lee and Yuan in 2004. The total number of syntheses stands at 6.

References

References

1. [http://www.alexis-biochemicals.com/Kendomycin.5+M5acc5c8c65d.0.html Kendomycin] {{Webarchive. link. (2008-05-16 at Alexis-Biochemicals)
2. (2000). "Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces". J. Chem. Soc. Perkin Trans. 1.
3. [http://www.chem.wisc.edu/~burke/Kendo.htm Burke Research Group] {{Webarchive. link. (2006-08-29 University of Wisconsin)
4. (2004). "Total Synthesis of Kendomycin: A Macro−C−Glycosidation Approach". J. Am. Chem. Soc..
5. (2006). "Evolution of a Total Synthesis of (−)-Kendomycin Exploiting a Petasis−Ferrier Rearrangement/Ring-Closing Olefin Metathesis Strategy". J. Am. Chem. Soc..
6. (2008). "Total Synthesis of (−)-Kendomycin". Org. Lett..
7. J. Am. Chem. Soc.. (2008). "Formal Synthesis of (−)-Kendomycin Featuring a Prins-Cyclization to Construct the Macrocycle"
8. (2009). "Total Synthesis of the Antibiotic Kendomycin by Macrocyclization using Photo-Fries Rearrangement and Ring-Closing Metathesis". Angewandte Chemie International Edition.
9. (2010). "In Pursuit of a Competitive Target: Total Synthesis of the Antibiotic Kendomycin". Angewandte Chemie International Edition.