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Isotropic formulations

Isotropic formulations are thermodynamically stable microemulsions possessing lyotropic liquid crystal properties. They inhabit a state of matter and physical behaviour somewhere between conventional liquids and that of solid crystals. Isotropic formulations are amphiphillic, exhibiting selective synchronicity with both the water and lipid phases of the substrate to which they are applied. Most recently, isotropic formulations have been used extensively in dermatology for drug delivery.

Uses

While it is well established that the skin provides an ideal site for the administration of local and systemic drugs, it presents a formidable barrier to the permeation of most substances. Isotropic formulations have been used to deliver drugs locally and systemically via the skin appendages, intercellular and transcellular routes.

References

References

  1. Leslie FM. “Continuum Theory for Nematic Liquid Crystals Continuum Mechanics and Thermodynamics.” 1992. 4 (3): 167 [https://doi.org/10.1007%2FBF01130288]
  2. Ghosh SK. “A Model for the Orientational Order in Liquid Crystals.” Il Nuovo Cimento D 1984 4 (3): 229 [https://doi.org/10.1007%2FBF02453342]
  3. Chen C, Han D, Cai C, Tang X. “An Overview of Liposome Lyopholisation and its Future Potential Journal of Controlled Release.” 2010; 142:299-311 [http://www.sciencedirect.com/science/article/pii/S0168365909007366]
  4. Gregoriadis G. “Lipsomes in Drug Delivery.” Harwood Academic Publishers, 1993; [https://books.google.com/books?id=IqqYFne6deEC&dq=Liposomes+in+Drug+Delivery&pg=PR7]
  5. Landman L. “The Epidermal Permeability Barrier.” Anat Embryol (Berl) 1988; 178:1-13 [https://doi.org/10.1007%2FBF00305008]
  6. Harada K. Murakami T. Yata N et al. “Role of Intercellular Lipids in Stratum Corneum in the Percutaneous Permeation of Drugs.” J Invest Dermatol 1992; 9 99: 278-282 [http://www.nature.com/jid/journal/v99/n3/abs/5611978a.html]
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