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Isolated atrial amyloidosis

Field	Value
specialty	cardiology

Isolated atrial amyloidosis (IAA) is a form of amyloidosis affecting the atria of the heart. It is caused by the deposition of misfolded atrial natriuretic factor (ANP) into the atrial wall.

In most forms of cardiac amyloidosis, amyloid accumulates in all cardiac structures, with the atria manifesting early in the disease due to factors that may include the haemodynamic effects of ventricular diastolic dysfunction, the physical disruption of the atrial wall by infiltrating amyloid, and the toxicity of the amyloid precursors to atrial cardiomyocytes. IAA is "isolated" in the sense that amyloidosis is restricted to the atria, resulting from local overproduction of ANP.

It may cause abnormal heart rhythms.

References

(November 2022). "Atrial amyloidosis: mechanisms and clinical manifestations". Eur J Heart Fail.
(2007). "Textbook of cardiovascular medicine". Lippincott Williams & Wilkins.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

amyloidosis heart-diseases protein-folding

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