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Isoflavonoid synthase

Class of enzymes

Field	Value
Name	Isoflavonoid synthase
EC_number	1.14.13.136

2-hydroxyisoflavanone synthase (, CYT93C, IFS, isoflavonoid synthase) is an enzyme with systematic name liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration). This enzyme catalyses the following chemical reactions:

: liquiritigenin + O2 + NADPH + H+ \rightleftharpoons 2,4',7-trihydroxyisoflavanone + H2O + NADP+ and : (2S)-naringenin + O2 + NADPH + H+ \rightleftharpoons 2,4',5,7-tetrahydroxyisoflavanone + H2O + NADP+

Isoflavonoid synthase requires cytochrome P450.

References

(October 1990). "Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis". FEBS Letters.
(September 2002). "Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase". The Plant Journal.
(May 2005). "Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue". Biochemical and Biophysical Research Communications.

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ec-1.14.13

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