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Interleukin-7 receptor

Protein found on the surface of cells

Summary

Protein found on the surface of cells

Field	Value
Name	Interleukin-7 receptor-α
HGNCid	6024
Symbol	IL7R
AltSymbols	CD127
EntrezGene	3575
OMIM	146661
RefSeq	NM_002185
UniProt	P16871
Chromosome	5
Arm	p
Band	13

'''IL-7 receptor and signaling''', common γ chain (blue) and IL-7 receptor-α (green)

The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132). The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15. Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.

Function

Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation . Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).

Diseases

Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia, multiple sclerosis, rheumatoid arthritis and juvenile idiopathic arthritis.

References

(November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science.
(December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science.
(December 1996). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng..
"IL2 family". IUPHAR/BPS.
"Entrez Gene: IL7R interleukin 7 receptor".
(October 2011). "Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia". Nat. Genet..
(September 2007). "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis". Nat. Genet..
(November 2009). "IL7RA polymorphisms and chronic inflammatory arthropathies". Tissue Antigens.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

type-i-cytokine-receptors

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