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Inositol-polyphosphate multikinase

Class of enzymes

Field	Value
Name	Inositol-polyphosphate multikinase
EC_number	2.7.1.151
CAS_number	9077-69-4

Inositol-polyphosphate multikinase (, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase. This enzyme catalyses the following chemical reaction

: 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate \rightleftharpoons 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction) :(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate \rightleftharpoons ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate :(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate \rightleftharpoons ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.

References

(November 1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology.
(March 2000). "A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control". Science.
(November 2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". The Journal of Biological Chemistry.
(January 2005). "The pathway for the production of inositol hexakisphosphate in human cells". The Journal of Biological Chemistry.

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