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Inositol-1,3,4-trisphosphate 5/6-kinase

FieldValue
Nameinositol-1,3,4-trisphosphate 5/6-kinase
EC_number2.7.1.159
CAS_number288307-53-9

** inositol-1,3,4-trisphosphate 5/6-kinase** (, Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase. This enzyme catalyses the following chemical reaction

: (1) ATP + 1D-myo-inositol 1,3,4-trisphosphate \rightleftharpoons ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate : (2) ATP + 1D-myo-inositol 1,3,4-trisphosphate \rightleftharpoons ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6).

References

References

  1. (May 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". The Journal of Biological Chemistry.
  2. (January 2005). "The pathway for the production of inositol hexakisphosphate in human cells". The Journal of Biological Chemistry.
  3. (April 2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Molecular Cell.
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