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Importin subunit alpha-1

Protein-coding gene in the species Homo sapiens

Summary

Protein-coding gene in the species Homo sapiens

Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA2 gene.

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import are members of the alpha importin family of karyopherins such as importin subunit alpha-1. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination

Interactions

Karyopherin alpha 2 has been shown to interact with:

ARL4A
ITK,
KPNB1,
PLAG1,
RECQL, and
SGK.

References

(Jun 1994). "Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein". Proceedings of the National Academy of Sciences of the United States of America.
(May 1995). "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences". Science.
"Entrez Gene: KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)".
(Dec 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". The Journal of Biological Chemistry.
(Oct 2001). "Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)". [[International Immunology]].
(Apr 2001). "Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta". Molecular and Cellular Biology.
(Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Molecular and Cellular Biology.
(Sep 1997). "Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor". Cell.
(May 2002). "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". The Journal of Biological Chemistry.
(May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL". Biochemical and Biophysical Research Communications.
(Mar 2003). "Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain". Molecular Biology of the Cell.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

armadillo-repeat-containing-proteins

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