From Surf Wiki (app.surf) — the open knowledge base

Immune receptor

Cell surface molecules of the immune system triggering changes in the behavior of cells

Schematic representation of an immune receptor

An immune receptor (or immunologic receptor) is a receptor, usually on a cell membrane, which binds to a ligand (usually another protein, such as cytokine) and causes a response in the immune system.

Types

The main receptors in the immune system are pattern recognition receptors (PRRs), Toll-like receptors (TLRs), killer activated and killer inhibitor receptors (KARs and KIRs), complement receptors, Fc receptors, B cell receptors and T cell receptors.

Receptor	Bind to	Function	Pattern recognition receptors (PRRs)
(e.g. TLRs, NLRs)	Killer activated and killer inhibitor receptors (KARs and KIRs)	Complement receptors	Fc receptors	B cell receptors	T cell receptors	Cytokine receptors
Pathogen-associated molecular patterns (PAMP)	Mediate cytokine production → inflammation → destroying pathogen
	Avails NK cells to identify abnormal host cells (KAR) or inhibit inappropriate host cell destruction (KIR)
Complement proteins on e.g. microbes	Allow phagocytic and B cells to recognize microbes and immune complexes
Epitope-antibody complexes	Stimulate phagocytosis
Epitopes	B cell differentiation into plasma cells and proliferation
Linear epitopes bound to MHC	Activate T cells
Cytokines	Regulation and co-ordination of immune responses

References

Lippincott's Illustrated Reviews: Immunology. Paperback: 384 pages. Publisher: Lippincott Williams & Wilkins; (July 1, 2007). Language: English. {{ISBN. 0-7817-9543-5. {{ISBN. 978-0-7817-9543-2. Page 20

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

immune-system single-pass-transmembrane-proteins transmembrane-receptors

Want to explore this topic further?

Ask Mako anything about Immune receptor — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report