IFNAR2

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.

Interactions

IFNAR2 has been shown to interact with:

• GNB2L1,
• IFNA2,
• STAT1, and
• STAT2.

References

References

1. (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell.
2. "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2".
3. (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol..
4. (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol..
5. (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem..
6. (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol..
7. (March 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem..