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ICE (chemotherapy)

ICE in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin lymphoma and Hodgkin lymphoma.

In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab. This regimen is then called ICE-R or R-ICE or RICE.

[R]-ICE regimen consists of:

Rituximab - an anti-CD20 monoclonal antibody, which is able to kill both normal and malignant CD20-bearing B cells;
Ifosfamide - an alkylating antineoplastic agent of the oxazafosforine group;
Carboplatin - a platinum-based antineoplastic drug, also an alkylating antineoplastic agent;
Etoposide - a topoisomerase inhibitor.

Dosing regimen

Drug	Dose	Mode	Days
Rituximab	375 mg/m2	IV infusion	Day 1
Ifosfamide	5000 mg/m2	IV continuous infusion over 24 hours	Day 2
Mesna for haemorrhagic cystitis prophylaxis with ifosfamide	5000 mg/m2	IV continuous infusion over 24 hours	Day 2
Carboplatin	Optimized to get AUC = 5 (max. 800 mg)	IV infusion	Day 2
Etoposide	100 mg/m2	IV infusion over 1 hour	Days 1-3
Filgrastim to shorten the period of neutropenia	5 μg/kg	S.C.	Days 5-12

Cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with autologous stem-cell transplantation follows (if the patient is considered eligible for HDCT and ASCT).

References

[http://jco.ascopubs.org/content/17/12/3776.full Ifosfamide, Carboplatin, and Etoposide: A Highly Effective Cytoreduction and Peripheral-Blood Progenitor-Cell Mobilization Regimen for Transplant-Eligible Patients With Non-Hodgkin’s Lymphoma]
[http://www.bloodjournal.org/content/103/10/3684.full?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=103&firstpage=3684&resourcetype=HWCIT&sso-checked=true Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma]

Info: Wikipedia Source

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chemotherapy-regimens-used-in-lymphoma

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