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Hydroxydione

Chemical compound

Chemical compound

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Hydroxydione, as hydroxydione sodium succinate (, , ) (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients. It was introduced in 1957, and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.

Chemistry

Related compounds include alfadolone, alfaxolone, dihydrodeoxycorticosterone, ganaxolone, minaxolone, pregnanolone, and renanolone.

References

References

  1. Anvisa. (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (January 2000). "Index Nominum 2000: International Drug Directory". Taylor & Francis.
  3. (1 January 2005). "Medicinal Chemistry". New Age International.
  4. William Andrew Publishing. (22 October 2013). "Pharmaceutical Manufacturing Encyclopedia, 3rd Edition". Elsevier.
  5. (14 September 2013). "The Wondrous Story of Anesthesia". Springer Science & Business Media.
  6. (22 October 2013). "Steroidal Activity in Experimental Animals and Man". Elsevier Science.
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5β-pregnanes primary-alcohols diketones gabaa-receptor-positive-allosteric-modulators general-anesthetics neurosteroids
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