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general/4-trifluoromethyl-phenyl-compounds

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Hydramethylnon

(3-(4-(trifluoromethyl)phenyl) -1-(2-(4-(trifluoromethyl)phenyl)ethenyl) -2-propenylidene)hydrazone | NFPA-H = 1 | NFPA-F = 1 | NFPA-R = 0 Hydramethylnon (AC 217,300) is an insecticide used primarily in the form of baits for cockroaches and ants. It works by inhibiting complex III in the mitochondrial inner membrane and leads to a halting of oxidative phosphorylation (IRAC class 20A). Some brands of hydramethylnon are Amdro, Blatex, Combat, Cyaforce, Cyclon, Faslane, Grant's, Impact, Matox, Maxforce, Pyramdron, Siege, Scuttle and Wipeout. Hydramethylnon is a slow-acting poison with delayed toxicity that needs to be eaten to be effective.

Toxicology

Hydramethylnon has low toxicity in mammals. The oral is 1100–1300 mg/kg in rats and above 28,000 mg/kg in dogs. Hydramethylnon is toxic to fish; the 96-hour LC50 in rainbow trout is 0.16 mg/L, 0.10 mg/L in channel catfish, and 1.70 mg/L in bluegill sunfish.

Hydramethylnon, when fed to rats for two years, led to an increase in uterine and adrenal tumors at the highest dose; therefore, the Environmental Protection Agency classifies hydramethylnon as a possible human carcinogen.

References

References

  1. (25 January 2019). "Modern Crop Protection Compounds". Wiley-VCH.
  2. [http://www.vspn.org/Library/misc/VSPN_M01289.htm Veterinary Support Personnel Network]
  3. "Hydramethylnon". [[PubChem]].
  4. "Hydramethylnon". National Pesticide Information Center.
Wikipedia Source

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4-(trifluoromethyl)phenyl-compounds alkene-derivatives hydrazones insecticides
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