Hybrid mass spectrometer

Notation

The different m/z separation elements of a hybrid mass spectrometer can be represented by a shorthand notation. The symbol Q represents a quadrupole mass analyzer, q is a radio frequency collision quadrupole, TOF is a time-of-flight mass spectrometer, B is a magnetic sector and E is an electric sector.

Sector quadrupole

A sector instrument can be combined with a collision quadrupole and quadrupole mass analyzer to form a hybrid instrument. A BEqQ configuration with a magnetic sector (B), electric sector (E), collision quadrupole (q) and m/z selection quadrupole (Q) have been constructed and an instrument with two electric sectors (BEEQ) has been described.

Quadrupole time-of-flight

A triple quadrupole mass spectrometer with the final quadrupole replaced by a time-of-flight device is known as a quadrupole time-of-flight instrument. Such an instrument can be represented as QqTOF.

Ion trap time-of-flight

In an ion trap instrument, ions are trapped in a quadrupole ion trap and then injected into the TOF. The trap can be 3-D or a linear trap.

Linear ion trap and Fourier transform mass analyzers

A linear ion trap combined with a Fourier transform ion cyclotron resonance or Orbitrap mass spectrometer is marketed by Thermo Scientific as the LTQ FT and LTQ Orbitrap, respectively.

References

References

1. (1982). "A new "hybrid" sector/quadrupole mass spectrometer for mass spectrometry/mass spectrometry". International Journal of Mass Spectrometry and Ion Physics.
2. (1985). "A hybrid BEQQ mass spectrometer". International Journal of Mass Spectrometry and Ion Processes.
3. Harrison, A.. (1986). "A hybrid BEQQ mass spectrometer for studies in gaseous ion chemistry". International Journal of Mass Spectrometry and Ion Processes.
4. (1992). "Hybrid BEEQ tandem mass spectrometer for the study of ion/surface collision processes". Review of Scientific Instruments.
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12. (January 2006). "Performance of a linear ion trap-Orbitrap hybrid for peptide analysis". Anal. Chem..