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HOT-7

Field	Value
verifiedrevid	411952705
image	HOT-7.svg
image_class	skin-invert-image
width	250px
routes_of_administration	Oral
class	Serotonergic psychedelic; Hallucinogen
ATC_prefix	None
metabolites	Possibly 2C-T-7
onset	Unknown
duration_of_action	6–8 hours
CAS_number_Ref
CAS_number	207740-39-4
PubChem	44350017
ChemSpiderID_Ref
ChemSpiderID	21106321
UNII_Ref
UNII	J43NT74JXX
ChEMBL_Ref
ChEMBL	127582
synonyms	4-Propylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-propylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-7; N-OH-2C-T-7
IUPAC_name	2-[2,5-Dimethoxy-4-(propylsulfanyl)phenyl]-N-hydroxyethan-1-amine
C	13	H=21	N=1	O=3	S=1
SMILES	COc1cc(SCCC)c(cc1CCNO)OC
StdInChI_Ref
StdInChI	1S/C13H21NO3S/c1-4-7-18-13-9-11(16-2)10(5-6-14-15)8-12(13)17-3/h8-9,14-15H,4-7H2,1-3H3
StdInChIKey_Ref
StdInChIKey	ASTNLROMDNGJLS-UHFFFAOYSA-N

| Drugs.com =

| elimination_half-life =

HOT-7, also known as 4-propylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-7, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families. It is the N-hydroxy derivative of 2C-T-7. The drug is taken orally.

Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists HOT-7's dose range as 15 to 20mg orally and its duration as 6 to 8hours. The drug's onset and peak of effects were not described. HOT-7's properties are similar to those of 2C-T-7, which has a dose of 10 to 30mg orally and a duration of 8 to 15hours, although HOT-7 may have a somewhat shorter duration. HOT-7 may act as a prodrug of 2C-T-7.

The effects of HOT-7 have been reported to include being "quite psychedelic", very rich in closed-eye imagery, not as much in terms of open-eye visuals, very good for interpretive and conceptual thinking, emotional changes, feeling "smoothly stoned", lightheadedness, alcohol-like tipsiness and wooziness, social avoidance, and gastrointestinal disturbances.

Interactions

Chemistry

Synthesis

The chemical synthesis of HOT-7 has been described.

Analogues

Analogues of HOT-7 include 2C-T-7, HOT-2 (N-hydroxy-2C-T-2), and HOT-17 (N-hydroxy-2C-T-17), among others.

History

HOT-7 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).

Society and culture

Legal status

Canada

HOT-7 is a controlled substance in Canada under phenethylamine blanket-ban language.

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.

References

{{CiteTiHKAL [http://www.erowid.org/library/books_online/pihkal/pihkal088.shtml]
{{CitePiHKAL https://www.erowid.org/library/books_online/pihkal/pihkal081.shtml "I first observed the intimate connection between an amine and a hydroxylamine with the discovery that N-hydroxy-MDA (MDOH) was equipotent and of virtually identical activity to the non-hydroxylated counterpart (MDA). And I have speculated in the recipe for MDOH about the possible biological interconversions of these kinds of compounds. And here, the simple addition of a hydroxyl group to the amine nitrogen atom of MDMA produces a new drug that is in most of its properties identical to MDMA. The concept has been extended to 2C-T-2, 2C-T-7, and 2C-T-17, where each of these three active compounds was structurally modified in exactly this way, by the addition of a hydroxyl group to the amine nitrogen atom. The results, HOT-2, HOT-7 and HOT-17 were themselves all active, and compared very closely with their non-hydroxylated prototypes."
"Controlled Drugs and Substances Act".
"UK Misuse of Drugs act 2001 Amendment summary". Isomer Design.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

designer-prodrugs hot-x-(psychedelics) pihkal propylthio-compounds psychedelic-phenethylamines

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