Host cell factor C1

Structure

HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.

Function

HCF1 is involved in control of the cell cycle as well as having regulatory roles in a multitude of processes related to transcription. Additionally, work in model organisms point to HCF1 as being a putative longevity determinant. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.

Mutations in this gene have been linked to disorders of the cobalamine metabolism.

Interactions

Host cell factor C1 has been shown to interact with:

• BAP1,
• CREB3,
• GABPA,
• HDAC1,
• HDAC2,
• MLL,
• OGT,
• PDCD2,
• POU2F1,
• PPP1CA,
• SIN3A,
• SP1,
• SUDS3,
• WDR5, and
• ZBTB17.

References

References

1. link. (2013-10-14)
2. (Jul 1993). "The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein". Cell.
3. "Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)".
4. (Sep 2008). "Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator". PLOS Biology.
5. (Sep 2013). "An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1". American Journal of Human Genetics.
6. (Dec 2009). "The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1". The Journal of Biological Chemistry.
7. (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". Journal of Virology.
8. (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes & Development.
9. (Feb 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". The EMBO Journal.
10. (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development.
11. (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene.
12. (Jan 1999). "HCF-dependent nuclear import of VP16". The EMBO Journal.
13. (Mar 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". The Journal of Biological Chemistry.
14. (Feb 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Research.
15. (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology.
16. (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry.