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Homospermidine synthase

Enzyme

Enzyme

FieldValue
NameHomospermidine synthase
EC_number2.5.1.44
CAS_number76106-84-8

Homospermidine synthase () is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming). This enzyme catalyses the following chemical reaction

: (1) 2 putrescine \rightleftharpoons sym-homospermidine + NH3 + H+ : (2) putrescine + spermidine \rightleftharpoons sym-homospermidine + propane-1,3-diamine

The reaction of this enzyme occurs in three steps.

References

References

  1. (February 1979). "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis [proceedings]". Biochemical Society Transactions.
  2. (1994). "Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation". Can. J. Chem..
  3. (July 1993). "Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105". Journal of Biochemistry.
  4. (August 1980). "Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings". The Biochemical Journal.
  5. (1996). "Homospermidine synthase of ''Rhodopseudomonas viridis'': Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of ''Escherichia coli''". J. Gen. Appl. Microbiol..
  6. (December 1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proceedings of the National Academy of Sciences of the United States of America.
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ec-2.5.1
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