Homarylamine

Use and effects

Homarylamine was briefly mentioned by Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved). According to Shulgin, homarylamine has been reported to be active as an antitussive (cough suppressant) at a dose of 30mg. No central effects were described as this dose. Shulgin tried this dose and experienced a little tightness of facial muscles, but no mental effects whatsoever.

Chemistry

Reactions

Reaction of homarylamine with formaldehyde gives hydrastinine.

A practical application of homarylamine is in the synthesis of .

Analogues

Analogues of homarylamine include homopiperonylamine (MDPEA), lobivine (MDDMPEA), lophophine (MMDPEA), MDA, MDMA, hydrastine, and hydrastinine, among others.

References

References

1. (1958). "International Non-Proprietary Names for Pharmaceutical Preparations". Chronicle of the World Health Organization.
2. {{US patent. 2820739
3. (March 1961). "Experimental Investigation of Nine Antitussive Drugs". Journal of Pharmaceutical Sciences.
4. (August 1944). "The Synthesis of l-Roemerine 1". Journal of the American Chemical Society.
5. {{CitePiHKAL "There is a family of compounds, to be discussed elsewhere, that is called the Muni-Metro (see under METHYL-J). The simplest member is this compound, MDPEA, and under its chemically acceptable synonym, homopiperonylamine, it can be called “H”. Following that code, then, the N-methyl homologue of MDPEA is METHYL-H, and it has been looked at, clinically, as an antitussive agent. N-METHYL-MDPEA, or METHYL-H, or N-methyl-3,4-methylenedioxyphenethylamine is effective in this role at dosages of about 30 milligrams, but I have read nothing that would suggest that there were any central effects. I have tried it at this level and have found a little tightness of the facial muscles, but there was nothing at all in the mental area."