HLA-DR8

Serology

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

Disease associations

DR8 is linked to papillary thyroid carcinomas, early onset pauciarticular juvenile chronic arthritis, primary biliary cirrhosis

by allele

HLA-DRB1*0801 is linked to primary biliary cirrhosis In Mexicans DR8 is found more often in type-2 juvenile diabetes.

HLA-DRB1*0803 is also linked to primary biliary cirrhosis

Genetic Linkage

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

References

References

1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
2. DR12 - 3%
3. (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas.". Clin Endocrinol.
4. (1994). "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis.". Clin Exp Rheumatol.
5. (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.". J Rheumatol.
6. (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.". Hepatology.
7. (2005). "Current concepts in the pathogenesis of primary biliary cirrhosis.". Ann Hepatol.
8. (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". [[Pediatric Diabetes]].