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general/hla-dr-haplotypes

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HLA-DR6

Broad-antigen serotype

HLA-DR6

Broad-antigen serotype

'''Illustration of HLA-DR'''

HLA-DR6 (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.

Serology

DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7.

Disease associations

DR13 and DR14 share a common association to myasthenia gravis.

Allele groups

HLA-DRB113 and HLA-DRB114 encode serotypes of DR6.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. DR12 - 3%, DR11 - 3% DR5-2%
  3. DR12 - 6%, DR11 - 7% DR5-4%
  4. DR1404 - 3%
  5. DR4 - 25%
  6. (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan.". Clin Immunol.
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