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general/hla-dr-haplotypes

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HLA-DR51

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.

DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution, having diverged from DRB1 approximately 4 million years ago.

DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.

Alleles

DRB5* is subdivided into two allele groups, DRB501 and DRB502. B501 encodes 14 alleles and 11 isoforms. B502 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.

DRB5*01 allele group

  • 14 Alleles: 11 proteins, 2 Nulls
  • DR51 Serotype: *0101, *0102
  • Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
  • Nulls: *0108N, *0110N

DRB5*02 allele group

  • 4 Alleles: 4 proteins
  • DR51 Serotype: *0202,
  • Serotype unknown: *0203 to *0205

Associated diseases

DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:

DRB50101:DRB11501 Multiple sclerosis, leprosy

DRB1 linkage

HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.

HLA-DR2

  • HLA-DR15 - DRB1*15
  • HLA-DR16 - DRB1*16

References

References

  1. (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic". Immunogenetics.
  2. (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol..
  3. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  4. (2006). "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.". J Immunol.
  5. (2000). "Human leukocyte antigens in forms of leprosy among Japanese patients.". Int J Lepr Other Mycobact Dis.
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