HLA-DR5

Serology

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy and Kaposi's sarcoma in AIDS, juvenile rheumatoid arthritis, pernicious anemia, Hashimoto's thyroiditis, mycosis fungoides, polyglandular deficiency syndrome, systemic sclerosis, childhood epilepsy, early-onset alopecia areata, short-ragweed Ra6 allergy, primary antiphospholipid syndrome, and increased longevity in the Dutch.

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

References

References

1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
2. DR8 - 2%
3. (1987). "HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia.". Tissue Antigens.
4. (1983). "Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma.". Tissue Antigens.
5. (1983). "HLA antigens in juvenile arthritis. Genetic basis for the different subtypes.". Arthritis Rheum.
6. (1980). "HLA-DR5 in juvenile rheumatoid arthritis confined to few joints.". Lancet.
7. (1981). "The association of goitrous autoimmune thyroiditis with HLA-DR5.". Tissue Antigens.
8. (1983). "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter.". J Clin Endocrinol Metab.
9. (1983). "Association of HLA-DR5 with mycosis fungoides.". J Invest Dermatol.
10. (1987). "The polyglandular deficiency syndrome: a new variant in Persian Jews.". J Endocrinol Invest.
11. (1987). "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families.". J Rheumatol.
12. (1987). "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles.". Arch Dermatol.
13. (1987). "On the association of the HLA system with epilepsy in children.". Epilepsia.
14. (1987). "Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata.". Dermatologica.
15. (1987). "Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans.". Immunogenetics.
16. (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum.
17. (1991). "Longevity and heredity in humans. Association with the human leucocyte antigen phenotype". Ann N Y Acad Sci.