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HLA-DR2

Antigen serotype

HLA-DR2

Antigen serotype

'''Illustration of HLA-DR'''

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB115 and HLA-DRB116 allele groups.

Serology

Disease associations

DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis, narcolepsy, tuberculoid leprosy (multi-drug-resistant tuberculosis or leprosy), ulcerative colitis (Japanese), primary biliary cirrhosis and autoimmune hepatitis. DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease.

Genetic linkage

DR2 is linked to the HLA-DR51.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed.". Hum Immunol.
  3. (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker.". J Infect Dis.
  4. (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens.
  5. (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis.". Gastroenterology.
  6. (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis.". Digestion.
  7. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum..
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