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general/hla-dr-haplotypes

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HLA-DR18

HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.

Serology

DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.

Disease associations

DR18 seropositivity is associated with rheumatoid polyarthritis

DRB1*0302 is positively associated with juvenile diabetes, nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.

Genetic Linkage

SerotypesDRADRB1DRB3DQA1DQB1DRB1HLA-AHLA -BDRB1
DR18(3)-DR52*0101*0302*0101
D18(3)-DQ2(2.5)*0501*0201*0302
A33-B58-DR18(3)*3301*5801*0302

HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA10501 and HLA DQB10201 alleles.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. (1997). "[Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal]". Dakar Med.
  3. (2006). "HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients". Bratislavské Lekárske Listy.
  4. (1997). "An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families". Brain.
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