HLA-DR17

Serology

DR17 recognizes the DRB1*0301, *0304 alleles.

Disease associations

By serotype

DR17 is associated with non-chronic sarcoidosis, infantile spasm/epilepsy, rabies vaccine-induced autoimmune encephalomyelitis and cardiovascular hypertrophy in subjects with arterial hypertension People with DR17 show a tendency toward benzylpenicilloyl allergies.

By allele

DRB1*0301: diabetes mellitus type 1, myositis, early onset Graves disease, type 1 autoimmune hepatitis, inflammatory inclusion body myositis. In autoimmune hepatitis, DRB1*0301 correlates with more severe and difficult to treat disease.

By haplotype

DRB10301:DQA105:DQB1*0201 is associated with diabetes mellitus type 1, ovarian cancer, non-thymomic myasthenia gravis, idiopathic inflammatory myopathies, non-cancer associated Lambert-Eaton myasthenic syndrome and sarcoidosis

By phenotype

The DRB10301/DRB11501 heterozygote is linked to primary Sjögren's syndrome

Genetic Linkage

HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA10501 and HLA DQB10201 alleles. DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:

A0101 : Cw0701 : B0801 : DRB10301 : DQA10501 : DQB10201

This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"

References

References

1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
2. (1997). "HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis.". Am J Respir Crit Care Med.
3. (2003). "T-lymphocyte activity in HLA-DR17 positive patients with active and clinically recovered sarcoidosis.". Sarcoidosis Vasc Diffuse Lung Dis.
4. (2001). "Contribution of the MHC class II antigens to the etiology of infantile spasm in Mexican Mestizos.". Epilepsia.
5. (1999). "Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis.". Ann Neurol.
6. (2001). "Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives.". Am J Hypertens.
7. (2006). "HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins". Chin. Med. J..
8. (2006). "HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients.". Bratisl Lek Listy.
9. (2006). "Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies.". Medicine (Baltimore).
10. (1997). "HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB10701,DQA10201 haplotype.". Tissue Antigens.
11. (1997). "Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis.". Hepatology.
12. (1997). "An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families". Brain.
13. (2007). "Current therapy for autoimmune hepatitis". Nature Clinical Practice Gastroenterology & Hepatology.
14. (2006). "Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?". Mediators Inflamm.
15. (2006). "HLA-class II haplotype associations with ovarian cancer". Int J Cancer.
16. (1999). "Correlation of thymic pathology with HLA in myasthenia gravis". Clinical Immunology.
17. (2000). "Update on the genetics of the idiopathic inflammatory myopathies". Curr Opin Rheumatol.
18. (2000). "Increased frequency of HLA class II alleles DRB10301 and DQB10201 in Lambert-Eaton myasthenic syndrome without associated cancer". Hum Immunol.
19. (2007). "HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB10301, and −DQB10201 haplotype in clinical variations of the disease". Tissue Antigens.
20. (1998). "DRB115 and DRB103 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility". Clin Exp Rheumatol.