HLA-DR16

Alleles

Disease associations

DR16 is associated with Chaga's cardiomyopathy, rheumatic heart disease, coronary artery ectasia, and chronic discoid lupus erythematosus.

DRB1*1601 is associated with tuberculosis risk

DRB1*1602: Juvenile rheumatoid arthritis, rheumatic heart disease, Takayasu arteritis , systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody, melioidosis (Burkholderia pseudomallei infection)

Extended linkage

DRB11601:DQA10102:DQB1*0502 haplotype is associated with tubeculousis risk

• 1602:DQA10102:DQB1*0502 haplotype: graves disease, cervical cancer (human papilloma virus infection), scleroderma
• 1602:DQA105:DQB1*0301 haplotype: rheumatic heart disease, systemic sclerosis

Genetic Linkage

HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.

References

References

1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
2. (2004). "MHC class I and class II genes in Mexican patients with Chagas disease.". Hum Immunol.
3. (2003). "MHC class II alleles in Mexican patients with rheumatic heart disease.". Int J Cardiol.
4. (2004). "HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia.". Acta Cardiol.
5. (2007). "Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients". Clin. Exp. Dermatol..
6. (2005). "Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report.". Tuberculosis (Edinb).
7. (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol.
8. (2000). "Association of HLA-DRB11602 and DRB11001 with in Colombian mestizos as markers of Amerindian ancestry.". Int J Cardiol.
9. (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody.". Arthritis Rheum.
10. (1999). "HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis).". Tissue Antigens.
11. (1998). "HLA-DR and -DQ associations with melioidosis.". Hum Immunol.
12. (2006). "The association between HLA class II haplotype with Graves' disease in Thai population.". Tissue Antigens.
13. (2005). "Association of HLA-DR and -DQ genes with Graves disease in Koreans.". Hum Immunol.
14. (2003). "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women.". Hum Immunol.
15. (1996). "Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype.". Arthritis Rheum.