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HLA-DR14

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

Alleles

Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462

Disease associations

DRB1*1402: juvenile rheumatoid arthritis, increased longevity in Okinawans.

Extended linkage

DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.

Genetic Linkage

DRA	DRB1	DRB3	DQA1
DR14(6)-DR52	*0101	*1401	*0201
*0101	*1402	*0201
*0101	*1403	*0101
DR14-DQ5(5.3, 1)	*0104	*0503	*1401
A11-B35-DR14(6)	*1101	*3501	*1401
A2-B51(5)-DR14(6)	*0201	*5101	*1401

HLA-DR13 is genetically linked to HLA-DR52 and HLA-DQ5 (HLA-DQ1) serotypes.

References

[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
DR1404 - 3%
DR4 - 25%
(2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol.
(2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology.
(2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol..

Info: Wikipedia Source

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