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general/hla-dr-haplotypes

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HLA-DR13

HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.

Alleles

Serotypes are unknown the following alleles: DRB1*1309, 1315 to 1379 **DRB113* allele group

  • 81 Alleles: 74 proteins
  • DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
  • DR6 (weak DR13) Serotype: *1308
  • DR13&Other serotypes: *1303, *1305, *1311,
  • Serotype unknown: *1309, *1315 to *1374

Disease associations

DRB1*1302 is linked to early childhood myastenia gravis. Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.

Extended linkage

DRB11302:DQA10102:DQB1*0604 Early childhood myastenia gravis

Genetic Linkage

DRADRB1DRB3DQA1DQB1DRB1HLA-AHLA-BDRB1
DR13(6)-DR52*0101*1301*0101
*0101*1301*0201
*0101*1302*0301
DR13(6)-DQ6(6.3, 1)*0103*0603*1301
DR13(6)-DQ6(6.4, 1)*0102*0604*1302
DR13(6)-DQ6(6.5, 1)*0102*0605*1302
DR13(6)-DQ6(6.9, 1)*0102*0609*1302
A2-Cw5-B44(16)-DR13*02*4402*1301

HLA-DR13 is genetically linked to DR52 and HLA-DQ6 (HLA-DQ1) serotypes.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. DR12 - 3%, DR11 - 3% DR5-2%
  3. DR12 - 6%, DR11 - 7% DR5-4%
  4. (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan.". Clin Immunol.
  5. (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol..
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